ArticleAmerican journal of respiratory cell and molecular biology2005
Monocytes recruited to the lungs of mice during immune inflammation ingest apoptotic cells poorly.
Article in American journal of respiratory cell and molecular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Recent advances in TAM mechanisms in lung diseases.Journal of translational medicine · 2025Review
- Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation.JCI insight · 2020Article
- Nox2-derived oxidative stress results in inefficacy of antibiotics against post-influenza S. aureus pneumonia.The Journal of experimental medicine · 2016Article
- Article
- TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- TAM receptor signaling in immune homeostasis.Annual review of immunology · 2015Review
- Assessing anti-fungal activity of isolated alveolar macrophages by confocal microscopy.Journal of visualized experiments : JoVE · 2014Article
- Advances in gene therapy technologies to treat retinitis pigmentosa.Clinical ophthalmology (Auckland, N.Z.) · 2014Review
- Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Virus-like particle-induced protection against MRSA pneumonia is dependent on IL-13 and enhancement of phagocyte function.The American journal of pathology · 2012Article
- Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPα.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages.The Journal of clinical investigation · 2010Article
- Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake.Frontiers in bioscience (Landmark edition) · 2009Review
- Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha.American journal of respiratory and critical care medicine · 2008Article
- Article
- Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen.Journal of immunology (Baltimore, Md. : 1950) · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Apoptotic cells must be cleared to resolve inflammation, but few resident alveolar macrophages (AMo) from normal lungs ingest apoptotic cells. We examined how Mo ingestion of apoptotic cells is altered during immune inflammation induced by intratracheal challenge of primed C57BL/6 mice using sheep red blood cells. Resident AMo were labeled in situ before challenge using intravenous PKH26 to distinguish them from recruited monocytes. Using flow cytometry, we identified phagocytosis of fluorescently-labeled apoptotic thymocytes by alveolar mononuclear phagocytes in vitro and in vivo, and measured surface molecule expression. Intratracheal challenge induced rapid recruitment of monocytes, peaking at Day 3 and decreasing thereafter, whereas numbers of resident AMo did not change significantly. At all times, the percentage of phagocytes ingesting apoptotic thymocytes in vitro was greater among resident AMo (28-45%) than among recruited monocytes (9-19%), but was low in both cell types relative to ingestion of immunoglobulin-opsonized targets. There was also a nonsignificant trend toward lower ingestion by monocytes in vivo. MerTK, a receptor tyrosine kinase crucial for apoptotic cell phagocytosis, was expressed by resident AMo, but not by recruited monocytes. Relative to resident AMo, monocytes recruited to the alveolus ingest apoptotic cells meagerly, possibly due to absence of MerTK expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.