ArticlePlant physiology2004
Glutamate dehydrogenase of tobacco is mainly induced in the cytosol of phloem companion cells when ammonia is provided either externally or released during photorespiration.
Article in Plant physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 116 citations in OpenAlex.
- NBPT improves root morphology and yield of cotton under salinity through changes in root nitrogen-metabolizing enzymes.Frontiers in plant science · 2026Article
- NAD(H) and NADP(H) in plants and mammals.Molecular plant · 2025Review
- Biochemical and Epigenetic Regulation of Glutamate Metabolism in Maize (Plants (Basel, Switzerland) · 2024Article
- Transcriptome Analysis of Macrophytes'Plants (Basel, Switzerland) · 2023Article
- The Key Role of Glutamate Dehydrogenase 2 (GDH2) in the Control of Kernel Production in Maize (Plants (Basel, Switzerland) · 2023Article
- Evolutionary implications of C2 photosynthesis: how complex biochemical trade-offs may limit C4 evolution.Journal of experimental botany · 2023Article
- Nitrogen metabolic rate and differential ammonia volatilization regulate resistance against opportunistic fungusFrontiers in plant science · 2022Article
- Proteomic and metabolomic analysis of Nicotiana benthamiana under dark stress.FEBS open bio · 2022Article
- Transport, functions, and interaction of calcium and manganese in plant organellar compartments.Plant physiology · 2021Review
- NADH-GOGAT Overexpression Does Not Improve Maize (Plants (Basel, Switzerland) · 2020Article
- Growth parameters of Liberibacter crescens suggest ammonium and phosphate as essential molecules in the Liberibacter-plant host interface.BMC microbiology · 2019Article
- Article
- The relationship between carbon and nitrogen metabolism in cucumber leaves acclimated to salt stress.PeerJ · 2018Article
- The Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease.Biology · 2017Review
- Article
- The transporter GAT1 plays an important role in GABA-mediated carbon-nitrogen interactions in Arabidopsis.Frontiers in plant science · 2015Article
- NADH-dependent glutamate synthase participated in ammonium assimilation in Arabidopsis root.Plant signaling & behavior · 2014Article
- Cessation of photosynthesis in Lotus japonicus leaves leads to reprogramming of nodule metabolism.Journal of experimental botany · 2013Article
- Plant plasma membrane-bound staphylococcal-like DNases as a novel class of eukaryotic nucleases.BMC plant biology · 2012Article
- Characterization of a NADH-dependent glutamate dehydrogenase mutant of Arabidopsis demonstrates the key role of this enzyme in root carbon and nitrogen metabolism.The Plant cell · 2012Article
Corrections and comments
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6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate (Glu) dehydrogenase (GDH) catalyses the reversible amination of 2-oxoglutarate for the synthesis of Glu using ammonium as a substrate. This enzyme preferentially occurs in the mitochondria of companion cells of a number of plant species grown on nitrate as the sole nitrogen source. For a better understanding of the controversial role of GDH either in ammonium assimilation or in the supply of 2-oxoglutarate (F. Dubois, T. Terce-Laforgue, M.B. Gonzalez-Moro, M.B. Estavillo, R. Sangwan, A. Gallais, B. Hirel [2003] Plant Physiol Biochem 41: 565-576), we studied the localization of GDH in untransformed tobacco (Nicotiana tabacum) plants grown either on low nitrate or on ammonium and in ferredoxin-dependent Glu synthase antisense plants. Production of GDH and its activity were strongly induced when plants were grown on ammonium as the sole nitrogen source. The induction mainly occurred in highly vascularized organs such as stems and midribs and was likely to be due to accumulation of phloem-translocated ammonium in the sap. GDH induction occurred when ammonia was applied externally to untransformed control plants or resulted from photorespiratory activity in transgenic plants down-regulated for ferredoxin-dependent Glu synthase. GDH was increased in the mitochondria and appeared in the cytosol of companion cells. Taken together, our results suggest that the enzyme plays a dual role in companion cells, either in the mitochondria when mineral nitrogen availability is low or in the cytosol when ammonium concentration increases above a certain threshold.
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