ArticlePlant physiology2004
Nitric oxide block of outward-rectifying K+ channels indicates direct control by protein nitrosylation in guard cells.
Article in Plant physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 138 citations in OpenAlex.
- Fusaric acid-mediated S-glutathionylation of MaAKT1 channel confers the virulence of Foc TR4 to banana.PLoS pathogens · 2025Article
- Mechanism of sodium nitroprusside regulating ginseng quality.Scientific reports · 2025Article
- Nitric oxide regulates photosynthesis and the capacity of the antioxidant system under water deficit and rehydration inFrontiers in plant science · 2025Article
- A network-based modeling framework reveals the core signal transduction network underlying high carbon dioxide-induced stomatal closure in guard cells.PLoS biology · 2024Article
- Scavenging of nitric oxide up-regulates photosynthesis under drought in Festuca arundinacea and F. glaucescens but reduces their drought tolerance.Scientific reports · 2022Article
- Membrane voltage as a dynamic platform for spatiotemporal signaling, physiological, and developmental regulation.Plant physiology · 2021Article
- Nitric oxide molecular targets: reprogramming plant development upon stress.Journal of experimental botany · 2019Review
- A new discrete dynamic model of ABA-induced stomatal closure predicts key feedback loops.PLoS biology · 2017Article
- The Membrane Transport System of the Guard Cell and Its Integration for Stomatal Dynamics.Plant physiology · 2017Review
- Excessive CellularFrontiers in plant science · 2017Article
- Convergence and Divergence of Signaling Events in Guard Cells during Stomatal Closure by Plant Hormones or Microbial Elicitors.Frontiers in plant science · 2016Review
- Hydrogen sulfide regulates inward-rectifying K+ channels in conjunction with stomatal closure.Plant physiology · 2015Article
- Plant Survival in a Changing Environment: The Role of Nitric Oxide in Plant Responses to Abiotic Stress.Frontiers in plant science · 2015Review
- Nitric oxide negatively regulates AKT1-mediated potassium uptake through modulating vitamin B6 homeostasis in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Clustering of the K+ channel GORK of Arabidopsis parallels its gating by extracellular K+.The Plant journal : for cell and molecular biology · 2014Article
- Polyamines control of cation transport across plant membranes: implications for ion homeostasis and abiotic stress signaling.Frontiers in plant science · 2014Review
- Nitric oxide in guard cells as an important secondary messenger during stomatal closure.Frontiers in plant science · 2013Review
- Nitric oxide and phytohormone interactions: current status and perspectives.Frontiers in plant science · 2013Review
- Nitric oxide as a key component in hormone-regulated processes.Plant cell reports · 2013Review
- Functions of S-nitrosylation in plant hormone networks.Frontiers in plant science · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recent work has indicated that nitric oxide (NO) and its synthesis are important elements of signal cascades in plant pathogen defense and are a prerequisite for drought and abscisic acid responses in Arabidopsis (Arabidopsis thaliana) and Vicia faba guard cells. Nonetheless, its mechanism(s) of action has not been well defined. NO regulates inward-rectifying K+ channels of Vicia guard cells through its action on Ca2+ release from intercellular Ca2+ stores, but alternative pathways are indicated for its action on the outward-rectifying K+ channels (I(K,out)), which are Ca2+ insensitive. We report here that NO affects I(K,out) when NO is elevated above approximately 10 to 20 nm. NO action on I(K,out) was consistent with oxidative stress and was suppressed by several reducing agents, the most effective being British anti-Lewisite (2,3-dimercapto-1-propanol). The effect of NO on the K+ channel was mimicked by phenylarsine oxide, an oxidizing agent that cross-links vicinal thiols. Neither intracellular pH buffering nor the phosphotyrosine kinase antagonist genistein affected NO action on I(K,out), indicating that changes in cytosolic pH and tyrosine phosphorylation are unlikely to contribute to NO or phenylarsine oxide action in this instance. Instead, our results strongly suggest that NO directly modifies the K+ channel or a closely associated regulatory protein, probably by nitrosylation of cysteine sulfhydryl groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.