ArticleAmerican journal of physiology. Heart and circulatory physiology2005
Sexual dimorphism in the permeability response of coronary microvessels to adenosine.
Article in American journal of physiology. Heart and circulatory physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Microvascular Sex- and Age- Dependent Phosphodiesterase Expression.Frontiers in aging · 2021Article
- Sex differences influencing micro- and macrovascular endothelial phenotype in vitro.The Journal of physiology · 2018Article
- Cardiac purinergic signalling in health and disease.Purinergic signalling · 2015Review
- Gender differences in response to cold pressor test assessed with velocity-encoded cardiovascular magnetic resonance of the coronary sinus.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2011Article
- Lymphatic fluid: exchange mechanisms and regulation.The Journal of physiology · 2011Article
- Gender differences affect blood flow recovery in a mouse model of hindlimb ischemia.American journal of physiology. Heart and circulatory physiology · 2011Article
- Cardiovascular sex differences influencing microvascular exchange.Cardiovascular research · 2010Review
- Intrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases.American journal of physiology. Heart and circulatory physiology · 2010Article
- Adaptation of coronary microvascular exchange in arterioles and venules to exercise training and a role for sex in determining permeability responses.American journal of physiology. Heart and circulatory physiology · 2007Article
- Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeability.American journal of physiology. Heart and circulatory physiology · 2006Article
- Sex-Specific Characteristics of the Microcirculation.Advances in experimental medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Gender influences volume regulation via several mechanisms; whether these include microvascular exchange, especially in the heart, is not known. In response to adenosine (Ado), permeability (P(s)) to protein of coronary arterioles of female pigs decreases acutely. Whether Ado induces similar P(s) changes in arterioles from males or whether equivalent responses occur in coronary venules of either sex has not been determined. Hypotheses that 1) basal P(s) properties and 2) P(s) responses to vasoactive stimuli are sex independent were evaluated from measures of P(s) to two hydrophilic proteins, alpha-lactalbumin and porcine serum albumin (PSA), in arterioles and venules isolated from hearts of adult male and female pigs. Consistent with hypothesis 1, basal P(s) values of both microvessel types were independent of sex. Contrary to hypothesis 2, P(s) responses to Ado varied with sex, protein, and vessel type. Confirming earlier studies, Ado induced a approximately 20% decrease in P(s) to both proteins in coronary arterioles from females. In arterioles from males, Ado did not change P(s) for alpha-lactalbumin (P(s)(alpha-lactalb), 3 +/- 13%), whereas P(s) for PSA (P(s)(PSA)) decreased by 27 +/- 8% (P < 0.005). In venules from females, Ado elevated P(s)(PSA) by 44 +/- 20% (P < 0.05), whereas in those from males, Ado reduced P(s)(PSA) by 24 +/- 5% (P < 0.05). The variety of outcomes is consistent with transvascular protein and protein-carried solute flux being regulated by multiple sex-dependent mechanisms in the heart and provides evidence of differences in exchange homeostasis of males and females in health and, likely, disease.
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Registered trials
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