ReviewBritish journal of clinical pharmacology2004
Current approaches to prevent NSAID-induced gastropathy--COX selectivity and beyond.
Review in British journal of clinical pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 131 citations in OpenAlex.
- Efficacy and safety of a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for pain relief in patients with osteoarticular diseases and dyspeptic symptoms.Drug design, development and therapy · 2018Trial
- A Review of Nonsteroidal Anti-Inflammatory Drugs for Food-Producing Animals With a Focus on Potential Applications for Farmed Finfish.Journal of fish diseases · 2026Review
- Integrative GC-MS, FT-IR, and Molecular Docking Analysis ofFood science & nutrition · 2026Article
- Gastric perforation at the extremes of age: a comparative case report of NSAID-associated high-grade dysplasia versus methamphetamine-induced ischemic perforation.International journal of emergency medicine · 2026Article
- Differential susceptibility to colonic ulceration in mice with genetic deletion ofResearch square · 2025Article
- Impact of Acid Suppressants on the Development ofInfection and drug resistance · 2025Article
- The relationship of redox signaling with the risk for atherosclerosis.Frontiers in pharmacology · 2024Review
- Umbilical Cord Mesenchymal Stem Cell Secretome Improves Clinical Outcomes and Changes Biomarkers in Knee Osteoarthritis.Journal of clinical medicine · 2023Article
- Computational Design, Synthesis, and Pharmacological Evaluation of Naproxen-Guaiacol Chimera for Gastro-Sparing Anti-Inflammatory Response by Selective COX2 Inhibition.Molecules (Basel, Switzerland) · 2022Article
- Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles.Journal of medicinal chemistry · 2022Article
- Analagesic and Anti-Inflammatory Potentials of a Less Ulcerogenic Thiadiazinethione Derivative in Animal Models: Biochemical and Histochemical Correlates.Drug design, development and therapy · 2022Article
- In Silico Approach Using Free Software to Optimize the Antiproliferative Activity and Predict the Potential Mechanism of Action of Pyrrolizine-Based Schiff Bases.Molecules (Basel, Switzerland) · 2021Article
- Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective.Biochemical pharmacology · 2020Review
- Anti-inflammatory, antioxidant, and gaso-protective mechanism of 3α-hydroxymasticadienoic acid and diligustilide combination on indomethacin gastric damage.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Methanolic Extract ofGastroenterology research and practice · 2020Article
- Differential effects of selective and non-selective cyclooxygenase inhibitors on fecal microbiota in adult horses.PloS one · 2018Article
- The non-invasive exfoliated transcriptome (exfoliome) reflects the tissue-level transcriptome in a mouse model of NSAID enteropathy.Scientific reports · 2017Article
- Genistein-attenuated Gastric Injury on Indomethacin-induced Gastropathy in Rats.Pharmacognosy magazine · 2017Article
- The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy.Gut microbes · 2016Article
- Protective activity of crocin against indomethacin-induced gastric lesions in rats.Journal of natural medicines · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastrointestinal (GI) toxicity associated with nonsteroidal anti-inflammatory drugs (NSAIDs) is still an important medical and socio-economic problem--despite recent pharmaceutical advances. To prevent NSAID-induced gastropathy, three strategies are followed in clinical routine: (i) coprescription of a gastroprotective drug, (ii) use of selective COX-2 inhibitors, and (iii) eradication of Helicobacter pylori. Proton pump inhibitors are the comedication of choice as they effectively reduce gastrointestinal adverse events of NSAIDs and are safe even in long-term use. Co-medication with vitamin C has only been little studied in the prevention of NSAID-induced gastropathy. Apart from scavenging free radicals it is able to induce haeme-oxgenase 1 in gastric cells, a protective enzyme with antioxidant and vasodilative properties. Final results of the celecoxib outcome study (CLASS study) attenuated the initial enthusiasm about the GI safety of selective COX-2 inhibitors, especially in patients concomitantly taking aspirin for cardiovascular prophylaxis. Helicobacter pylori increases the risk for ulcers particularly in NSAID-naive patients and therefore eradication is recommended prior to long-term NSAID therapy at least in patients at high risk. New classes of COX-inhibitors are currently evaluated in clinical studies with very promising results: NSAIDs combined with a nitric oxide releasing moiety (NO-NSAID) and dual inhibitors of COX and 5-LOX. These drugs offer extended anti-inflammatory potency while sparing gastric mucosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.