Evidence map›Paper›PMID 15561871›Full record

ArticleAntimicrobial agents and chemotherapy2004

Glucocorticoids increase in vitro and in vivo activities of antibiotics against Chlamydophila pneumoniae.

Dario Caronzolo, Valeria Lucini, Marilou Pannacci, Silvia Grosso, Federica Colleoni, Franco Fraschini, Francesco Scaglione

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dario CaronzoloDepartment of Pharmacology, Chemotherapy and Toxicology, University of Milan, Milan, Italy.
Valeria Lucini
Marilou Pannacci
Silvia Grosso
Federica Colleoni
Franco Fraschini
Francesco Scaglione
University of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The in vitro and in vivo antichlamydial activities of dexamethasone and beclomethasone alone and in combination with an antibiotic were tested. In vitro, dexamethasone and beclomethasone decreased the number of inclusion-forming units versus the control number (P < 0.001). The combination of glucocorticoids with azithromycin, telithromycin, or levofloxacin was more active than antibiotics used alone (P < 0.001). The combination, tested in a murine Chlamydophila pneumoniae infection model, produced similar results.

Indexed as

AnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsAzithromycinCell LineChlamydophila InfectionsChlamydophila pneumoniaeDexamethasoneDrug SynergismGlucocorticoidsHumansKetolidesLevofloxacinMiceMice, Inbred BALB CMicrobial Sensitivity TestsAnti-Bacterial AgentsAnti-Inflammatory AgentsAzithromycinDexamethasoneGlucocorticoidsKetolidesLevofloxacinOfloxacintelithromycin

Identifiers

PMID15561871
PMCPMC529217
OpenAlexW2161717250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.