ArticleAntimicrobial agents and chemotherapy2004
Molecular and kinetic comparison of the novel extended-spectrum beta-lactamases CTX-M-25 and CTX-M-26.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- The occurrence of CTX-M-25-producing Enterobacteriaceae in day-old broiler chicks in Japan.The Journal of veterinary medical science · 2017Article
- Escherichia coli β-Lactamases: What Really Matters.Frontiers in microbiology · 2016Review
- bla CTX-M-152, a Novel Variant of CTX-M-group-25, Identified in a Study Performed on the Prevalence of Multidrug Resistance among Natural Inhabitants of River Yamuna, India.Frontiers in microbiology · 2016Article
- Epidemiology and genetics of CTX-M extended-spectrum β-lactamases in Gram-negative bacteria.Critical reviews in microbiology · 2013Review
- Characterization of two new CTX-M-25-group extended-spectrum β-lactamase variants identified in Escherichia coli isolates from Israel.PloS one · 2012Article
- CTX-M Enzymes: Origin and Diffusion.Frontiers in microbiology · 2012Article
- Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis.Antimicrobial agents and chemotherapy · 2011Article
- Novel chromosome-encoded CTX-M-78 beta-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup.Antimicrobial agents and chemotherapy · 2010Article
- Phenotypic and molecular characterization of two novel CTX-M enzymes carried by Klebsiella pneumoniae.Molecular biology reports · 2010Article
- Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg.Antimicrobial agents and chemotherapy · 2009Article
- Identification of CTX-M-type extended-spectrum-beta-lactamase genes using real-time PCR and pyrosequencing.Antimicrobial agents and chemotherapy · 2007Article
- First report of extended-spectrum-beta-lactamase-producing Salmonella enterica isolates in Ireland.Antimicrobial agents and chemotherapy · 2006Article
- Prediction of the evolution of ceftazidime resistance in extended-spectrum beta-lactamase CTX-M-9.Antimicrobial agents and chemotherapy · 2006Article
- CTX-M-2 and a new CTX-M-39 enzyme are the major extended-spectrum beta-lactamases in multiple Escherichia coli clones isolated in Tel Aviv, Israel.Antimicrobial agents and chemotherapy · 2005Article
- Transcriptional analysis of the bla(CTX-M-2) gene in Salmonella enterica serovar Infantis.Antimicrobial agents and chemotherapy · 2005Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CTX-M-25 is a novel extended-spectrum beta-lactamase isolated from a single Canadian Escherichia coli isolate. Susceptibility testing demonstrated that this enzyme confers resistance to both cefotaxime and ceftazidime, but the level of resistance was reduced with the addition of beta-lactamase inhibitors. The bla(CTX-M-25) gene was detected on a 111-kb plasmid. It is a member of the CTX-M-8 group and has the closest amino acid identity (99%; three amino acid substitutions) with CTX-M-26. The bla(CTX-M-26) gene was detected on a 100-kb plasmid isolated from a Klebsiella pneumoniae strain from the United Kingdom, and plasmid profiling revealed that it showed some homology to the bla(CTX-M-25)-harboring plasmid. Both CTX-M genes were located downstream of ISEcp1, although the copy upstream of bla(CTX-M-25) was disrupted by IS50-A. Comparative kinetic studies of recombinant CTX-M-25 and CTX-M-26 enzymes showed that CTX-M-25 has a higher level of ceftazidime hydrolysis (kcat values, 33 and 0.005 s(-1) for CTX-M-25 and CTX-M-26, respectively).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.