Evidence map›Paper›PMID 15561731›Full record

SynthesisBMJ (Clinical research ed.)2004

Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomised placebo controlled trials.

Jan Magnus Bjordal, Anne Elisabeth Ljunggren, Atle Klovning, Lars Slørdal

2 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 140 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 20 pooled it
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04190797 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Photobiomodulation on Postoperative Pain

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2019 to 2020Enrolled34ConditionsKnee Osteoarthritis, Metabolic DiseaseArmsPhotobiomodulation + patiente controled anaethesia (PCA), Placebo + patiente controled anaethesia (PCA)
NCT06554483 nacompletednot on this mapstarted 2024, after this paper: background citation

The Effects of Neuroscience Based Proprioceptive Exercise Training in Elderly With Chronic Knee Pain

TypeinterventionalSponsorPamukkale UniversityRan2024 to 2024Enrolled24ConditionsChronic Knee Pain, Pain, Chronic, ElderlyArmsExercise
3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 20 syntheses or guidelines pooled it, 448 citations in OpenAlex.

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  8. Guideline
  9. Tramadol for osteoarthritis.The Cochrane database of systematic reviews · 2019
    Pooled it
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  16. The Hip and Knee Book: developing an active management booklet for hip and knee osteoarthritis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2010
    Pooled it
  17. Acupuncture for peripheral joint osteoarthritis.The Cochrane database of systematic reviews · 2010
    Pooled it
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  20. Osteoarthritis of the knee.BMJ clinical evidence · 2007
    Pooled it

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jan Magnus BjordalDepartment of Public Health and Primary Health Care, University of Bergen, 5018 Bergen, Norway. jmb@hib.no
Anne Elisabeth Ljunggren
Atle Klovning
Lars Slørdal
University of Bergen · NONorwegian University of Science and Technology · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo estimate the analgesic efficacy of non-steroidal anti-inflammatory drugs (NSAIDs), including selective cyclo-oxygenase-2 inhibitors (coxibs), in patients with osteoarthritis of the knee.

designSystematic review and meta-analysis of randomised placebo controlled trials. STUDIES REVIEWED: 23 trials including 10 845 patients, median age of 62.5 years. 7807 patients received adequate doses of NSAIDs and 3038 received placebo. The mean weighted baseline pain score was 64.2 mm on 100 mm visual analogue scale (VAS), and average duration of symptoms was 8.2 years.

main outcome measureChange in overall intensity of pain.

resultsMethodological quality of trials was acceptable, but 13 trials excluded patients before randomisation if they did not respond to NSAIDs. One trial provided long term data for pain that showed no significant effect of NSAIDs compared with placebo at one to four years. The pooled difference for pain on visual analogue scale in all included trials was 10.1 mm (95% confidence interval 7.4 to 12.8) or 15.6% better than placebo after 2-13 weeks. The results were heterogeneous, and the effect size for pain reduction was 0.32 (0.24 to 0.39) in a random effects model. In 10 trials that did not exclude non-responders to NSAID treatment the results were homogeneous, with an effect size for pain reduction of 0.23 (0.15 to 0.31).

conclusionNSAIDs can reduce short term pain in osteoarthritis of the knee slightly better than placebo, but the current analysis does not support long term use of NSAIDs for this condition. As serious adverse effects are associated with oral NSAIDs, only limited use can be recommended.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsHumansIsoenzymesMembrane ProteinsMiddle AgedOsteoarthritis, KneePainPersons with DisabilitiesProstaglandin-Endoperoxide SynthasesRandomized Controlled Trials as TopicTreatment OutcomeAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsIsoenzymesMembrane ProteinsProstaglandin-Endoperoxide SynthasesPTGS2 protein, human

Identifiers

PMID15561731
PMCPMC534841
OpenAlexW2106903173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.