ArticleJournal of muscle research and cell motility1992
Caldesmon content of mammalian smooth muscles.
Article in Journal of muscle research and cell motility, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 46 citations in OpenAlex.
- Ablation of smooth muscle caldesmon affects the relaxation kinetics of arterial muscle.Pflugers Archiv : European journal of physiology · 2013Article
- New insights into the regulation of the actin cytoskeleton by tropomyosin.International review of cell and molecular biology · 2010Review
- Caldesmon and the regulation of cytoskeletal functions.Advances in experimental medicine and biology · 2008Review
- Calponin (CaP) as a latch-bridge protein--a new concept in regulation of contractility in smooth muscles.Journal of muscle research and cell motility · 2004Review
- Caldesmon exhibits a clustered distribution along individual chicken gizzard native thin filaments.Journal of muscle research and cell motility · 2001Article
- Contractile properties and proteins of smooth muscles of a calponin knockout mouse.The Journal of physiology · 2000Article
- Targeted expression of SV40 large T-antigen to visceral smooth muscle induces proliferation of contractile smooth muscle cells and results in megacolon.The Journal of biological chemistry · 1999Article
- Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells.The Journal of cell biology · 1996Article
- The effects of caldesmon extraction on mechanical properties of skinned smooth muscle fibre preparations.Pflugers Archiv : European journal of physiology · 1996Article
- Immunocytochemical localization of caldesmon and calponin in chicken gizzard smooth muscle.Journal of muscle research and cell motility · 1996Article
- Flexation of caldesmon: effect of conformation on the properties of caldesmon.Journal of muscle research and cell motility · 1995Article
- Phosphorylation of caldesmon by mitogen-activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle.The Journal of physiology · 1995Article
- Heterogeneity of smooth muscle-associated proteins in mammalian brain microvasculature.Cell and tissue research · 1995Article
- Calmodulin and the regulation of smooth muscle contraction.Molecular and cellular biochemistry · 1994Review
- Caldesmon and a 20-kDa actin-binding fragment of caldesmon inhibit tension development in skinned gizzard muscle fiber bundles.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Ca2+ regulation of the contractile apparatus in canine gastric smooth muscle.The Journal of physiology · 1993Article
- A comparison of the effects of calponin on smooth and skeletal muscle actomyosin systems in the presence and absence of caldesmon.The Biochemical journal · 1992Article
- Novel immunological technique.Journal of muscle research and cell motility · 1992Article
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3 authors at 2 institutions in 1 country.
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Abstract
In the present study we have used a quantitative immunoblotting method to measure the caldesmon content of a variety of smooth muscles with distinctly different contractile phenotypes. Two tonic vascular smooth muscles and several phasic smooth muscles were examined. The caldesmon, actin and myosin contents of each muscle type were measured. Smooth muscle from large arteries (i.e. bovine aorta and porcine carotid artery) had the lowest caldesmon content and phasic muscles (e.g. rat uterus and guinea pig taenia coli) had the highest. The molar ratio of monomeric caldesmon to monomeric actin was 1:205 for the aorta and carotid artery versus 1:22-28 for the taenia coli and uterus. The molar ratio of caldesmon to monomeric myosin heavy chain was 1:9 for the aorta and carotid versus 1:2 for the uterus and taenia coli. The caldesmon contents of canine trachealis and rabbit ileum were intermediate between these extremes. Evidence was found for the presence of both tissue- and species-specific caldesmon isoforms. The relatively high caldesmon content in rat uterus and guinea pig taenia coli suggests the possibility that the contractile phenotype associated with phasic smooth muscles may be dependent on the presence of caldesmon.
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