ArticleThe Journal of cell biology1992
Mechanisms of cell shape change: the cytomechanics of cellular response to chemical environment and mechanical loading.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Vasoactive agonists exert dynamic and coordinated effects on vascular smooth muscle cell elasticity, cytoskeletal remodelling and adhesion.The Journal of physiology · 2014Article
- Micropatterning of single endothelial cell shape reveals a tight coupling between nuclear volume in G1 and proliferation.Biophysical journal · 2008Article
- The mechanobiological aetiopathogenesis of tendinopathy: is it the over-stimulation or the under-stimulation of tendon cells?International journal of experimental pathology · 2007Review
- Isostaticity and controlled force transmission in the cytoskeleton: A model awaiting experimental evidence.Biophysical journal · 2006Article
- Direct observations of the mechanical behaviors of the cytoskeleton in living fibroblasts.The Journal of cell biology · 1999Article
- Theoretical estimates of mechanical properties of the endothelial cell cytoskeleton.Biophysical journal · 1996Article
- Auxins and Cytokinins as Antipodal Modulators of Elasticity within the Actin Network of Plant Cells.Plant physiology · 1996Article
- Measuring the viscoelastic properties of human platelets with the atomic force microscope.Biophysical journal · 1996Article
- Covalent immobilization as a stimulus of cell wall composition changes.Experientia · 1995Article
- Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium.The Journal of clinical investigation · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Processes such as cell locomotion and morphogenesis depend on both the generation of force by cytoskeletal elements and the response of the cell to the resulting mechanical loads. Many widely accepted theoretical models of processes involving cell shape change are based on untested hypotheses about the interaction of these two components of cell shape change. I have quantified the mechanical responses of cytoplasm to various chemical environments and mechanical loading regimes to understand better the mechanisms of cell shape change and to address the validity of these models. Measurements of cell mechanical properties were made with strands of cytoplasm submerged in media containing detergent to permeabilize the plasma membrane, thus allowing control over intracellular milieu. Experiments were performed with equipment that generated sinusoidally varying length changes of isolated strands of cytoplasm from Physarum polycephalum. Results indicate that stiffness, elasticity, and viscosity of cytoplasm all increase with increasing concentration of Ca2+, Mg2+, and ATP, and decrease with increasing magnitude and rate of deformation. These results specifically challenge assumptions underlying mathematical models of morphogenetic events such as epithelial folding and cell division, and further suggest that gelation may depend on both actin cross-linking and actin polymerization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.