ArticleOncogene2005
Silencing of human Int-6 impairs mitosis progression and inhibits cyclin B-Cdk1 activation.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis.Nature communications · 2023Article
- Side-Population Trophoblasts Exhibit the Differentiation Potential of a Trophoblast Stem Cell Population, Persist to Term, and are Reduced in Fetal Growth Restriction.Stem cell reviews and reports · 2020Article
- Eukaryotic translation initiation factor 3 (eIF3) subunit e is essential for embryonic development and cell proliferation.FEBS open bio · 2018Article
- The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure.PLoS genetics · 2017Article
- Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation.Biochimica et biophysica acta · 2016Article
- The Rice Eukaryotic Translation Initiation Factor 3 Subunit e (OseIF3e) Influences Organ Size and Pollen Maturation.Frontiers in plant science · 2016Article
- Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells.Cell & bioscience · 2015Article
- Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells.International journal of molecular sciences · 2014Article
- Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis.Cell cycle (Georgetown, Tex.) · 2013Article
- Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells.Oncogene · 2013Article
- The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.Journal of virology · 2012Article
- INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.RNA (New York, N.Y.) · 2012Article
- Article
- An oncogenic role of eIF3e/INT6 in human breast cancer.Oncogene · 2010Article
- Expression of human eukaryotic initiation factor 3f oscillates with cell cycle in A549 cells and is essential for cell viability.Cell division · 2010Article
- Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation.Cell cycle (Georgetown, Tex.) · 2010Article
- Arabidopsis eIF3e interacts with subunits of the ribosome, Cop9 signalosome and proteasome.Plant signaling & behavior · 2008Article
- Article
- The INT6 cancer gene and MEK signaling pathways converge during zebrafish development.PloS one · 2007Article
- Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.Oncogene · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Int-6 protein has been originally identified as the product of a mouse gene being a frequent integration site of the mouse mammary tumour virus. Here, we show that reducing Int-6 expression by RNA interference in HeLa cells markedly alters mitosis progression. Defects in spindle formation, chromosome segregation and cytokinesis were observed. These abnormalities of mitosis completion are correlated with an inhibition of cyclin B-Cdk1 kinase activity, due to a prolonged inhibitory phosphorylated state of Cdk1. In line with this observation, the Wee1 tyrosine kinase that negatively controls Cdk1 was less efficiently inactivated during G2 in Int-6-depleted cells. These findings support the notion that the oncogenic properties associated with alteration of Int-6 originate from chromosomal instability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.