ReviewJournal of mammary gland biology and neoplasia2004
Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis.
Review in Journal of mammary gland biology and neoplasia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
- Cellular plasticity and metastasis in breast cancer: a pre- and post-malignant problem.Journal of cancer metastasis and treatment · 2019Article
- PHLDA1 (pleckstrin homology-like domain, family A, member 1) knockdown promotes migration and invasion of MCF10A breast epithelial cells.Cell adhesion & migration · 2018Article
- Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors.Nature communications · 2017Article
- p16INK4a suppresses BRCA1-deficient mammary tumorigenesis.Oncotarget · 2016Article
- Genomic Changes in Normal Breast Tissue in Women at Normal Risk or at High Risk for Breast Cancer.Breast cancer : basic and clinical research · 2016Review
- Epigenetic linkage of aging, cancer and nutrition.The Journal of experimental biology · 2015Review
- Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis.Clinical epigenetics · 2015Article
- Retinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, and therapeutic interventions.Breast cancer research : BCR · 2014Review
- Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation.Epigenetics · 2014Article
- Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis.Breast cancer research : BCR · 2012Review
- Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances.Genes, chromosomes & cancer · 2012Article
- Study of promoter methylation pattern of 14-3-3 sigma gene in normal and cancerous tissue of breast: A potential biomarker for detection of breast cancer in patients.Advanced biomedical research · 2012Article
- YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification.Oncogene · 2011Article
- YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention.Oncotarget · 2011Article
- p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells.Aging cell · 2010Article
- A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention.Molecular cancer · 2010Article
- Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies.Breast cancer research : BCR · 2010Article
- A computational approach to resolve cell level contributions to early glandular epithelial cancer progression.BMC systems biology · 2009Article
- Promoter Hypermethylation in Tumor Suppressing Genes p16 and FHIT and Their Relationship with Estrogen Receptor and Progesterone Receptor Status in Breast Cancer Patients from Northern India.Translational oncology · 2009Article
- Seed in soil, with an epigenetic view.Biochimica et biophysica acta · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies of human mammary epithelial cells from healthy individuals are providing novel insights into how early epigenetic and genetic events affect genomic integrity and fuel carcinogenesis. Key epigenetic changes, such as the hypermethylation of the p16 (INK4a) promoter sequences, create a previously unappreciated preclonal phase of tumorigenesis in which a subpopulation of mammary epithelial cells are positioned for progression to malignancy (Romanov et al. , 2001, Nature , 409:633-637; Tlsty et al. , 2001, J. Mammary Gland Biol. Neoplasia , 6:235-243). These key changes precede the clonal outgrowth of premalignant lesions and occur frequently in healthy, disease-free women. Understanding more about these early events should provide novel molecular candidates for prevention and therapy of breast cancer that target the process instead of the consequences of genomic instability. This review will highlight some of the key alterations that have been studied in human mammary epithelial cells in culture and relate them to events observed in vivo and discussed in accompanying reviews in this volume.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.