ArticleInfection and immunity2004
Differential regulation of inflammatory cytokine secretion by human dendritic cells upon Chlamydia trachomatis infection.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 83 citations in OpenAlex.
- Proinflammatory Cytokines in Women with PCOS in Atypical Pathogen Infections.Diagnostics (Basel, Switzerland) · 2025Article
- Gram-negative bacteria activate cellular pathways in plaque microenvironment; Systems biology approach.BMC microbiology · 2025Article
- NK Cells Modulate Dendritic Cell (DC) Signaling Pathways and DC Recruitment in Chlamydial Infection.International journal of molecular sciences · 2025Article
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- Gingival transcriptomic patterns of macrophage polarization during initiation, progression, and resolution of periodontitis.Clinical and experimental immunology · 2023Article
- Mast cells selectively produce inflammatory mediators and impact the early response toFrontiers in immunology · 2023Article
- TLR4/CD14/MD2 Revealed as the Limited Toll-like Receptor Complex forMicroorganisms · 2022Article
- Human genetic diversity regulating theHGG advances · 2022Article
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- Insights Into Host Cell Cytokines inFrontiers in immunology · 2021Review
- Chronic testicular Chlamydia muridarum infection impairs mouse fertility and offspring development†.Biology of reproduction · 2020Article
- Role of Endoplasmic Reticulum Stress in Proinflammatory Cytokine-Mediated Inhibition of Trophoblast Invasion in Placenta-Related Complications of Pregnancy.The American journal of pathology · 2019Article
- Water Filtered Infrared A and Visible Light (wIRA/VIS) Irradiation ReducesFrontiers in microbiology · 2018Article
- Mito-xenophagic killing of bacteria is coordinated by a metabolic switch in dendritic cells.Scientific reports · 2017Article
- Chlamydia trachomatis Cellular Exit Alters Interactions with Host Dendritic Cells.Infection and immunity · 2017Article
- Article
- Danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae.Biomedical journal · 2016Review
- Macrophage polarization in response to oral commensals and pathogens.Pathogens and disease · 2016Article
- Inflammasomes and Their Role in Innate Immunity of Sexually Transmitted Infections.Frontiers in immunology · 2016Review
- Human and Pathogen Factors Associated with Chlamydia trachomatis-Related Infertility in Women.Clinical microbiology reviews · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Chlamydia trachomatis is an obligate intracellular gram-negative bacterium responsible for a wide spectrum of diseases in humans. Both genital and ocular C. trachomatis infections are associated with tissue inflammation and pathology. Dendritic cells (DC) play an important role in both innate and adaptive immune responses to microbial pathogens and are a source of inflammatory cytokines. To determine the potential contribution of DC to the inflammatory process, human DC were infected with C. trachomatis serovar E or L2. Both C. trachomatis serovars were found to infect and replicate in DC. Upon infection, DC up-regulated the expression of costimulatory (B7-1) and cell adhesion (ICAM-1) molecules. Furthermore, chlamydial infection induced the secretion of interleukin-1beta (IL-1beta), IL-6, IL-8, IL-12p70, IL-18, and tumor necrosis factor alpha (TNF-alpha). The mechanisms involved in Chlamydia-induced IL-1beta and IL-18 secretion differed from those of the other cytokines. Chlamydia-induced IL-1beta and IL-18 secretion required infection with viable bacteria and was associated with the Chlamydia-induced activation of caspase-1 in infected host cells. In contrast, TNF-alpha and IL-6 secretion did not require that the Chlamydia be viable, suggesting that there are at least two mechanisms involved in the Chlamydia-induced cytokine secretion in DC. Interestingly, an antibody to Toll-like receptor 4 inhibited Chlamydia-induced IL-1beta, IL-6, and TNF-alpha secretion. The data herein demonstrate that DC can be infected by human C. trachomatis serovars and that chlamydial components regulate the secretion of various cytokines in DC. Collectively, these data suggest that DC play a role in the inflammatory processes caused by chlamydial infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.