ArticleInfection and immunity2004
Identification of two Mycobacterium marinum loci that affect interactions with macrophages.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Mycolic Acid-like Lipids Act as Substrates forACS omega · 2025Article
- Nanotherapeutic delivery of antibiotic cocktail enhances intra-macrophage killing ofFrontiers in antibiotics · 2023Article
- EphH, a unique epoxide hydrolase encoded by Rv3338 is involved in the survival ofFrontiers in microbiology · 2022Article
- Diversity and evolution of bacterial bioluminescence genes in the global ocean.NAR genomics and bioinformatics · 2020Article
- Evaluation of in silico designed inhibitors targeting MelF (Rv1936) against Mycobacterium marinum within macrophages.Scientific reports · 2019Article
- Mce3R Stress-Resistance Pathway Is Vulnerable to Small-Molecule Targeting That Improves Tuberculosis Drug Activities.ACS infectious diseases · 2019Article
- More than cholesterol catabolism: regulatory vulnerabilities in Mycobacterium tuberculosis.Current opinion in chemical biology · 2018Review
- Article
- MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected byFrontiers in immunology · 2017Article
- EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5.Scientific reports · 2016Article
- Article
- Random inducible controlled expression (RICE) for identification of mycobacterial virulence genes.Tuberculosis (Edinburgh, Scotland) · 2011Article
- Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination.Infection and immunity · 2009Article
- The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor.Journal of molecular biology · 2008Article
- Use of gene dosage effects for a whole-genome screen to identify Mycobacterium marinum macrophage infection loci.Infection and immunity · 2008Article
- The Mycobacterium marinum mel2 locus displays similarity to bacterial bioluminescence systems and plays a role in defense against reactive oxygen and nitrogen species.BMC microbiology · 2007Article
- A Mycobacterium marinum mel2 mutant is defective for growth in macrophages that produce reactive oxygen and reactive nitrogen species.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Mycobacterium marinum is closely related to Mycobacterium tuberculosis, the cause of tuberculosis in humans. M. marinum has become an important model system for the study of the molecular mechanisms involved in causing tuberculosis in humans. Through molecular genetic analysis of the differences between pathogenic and nonpathogenic mycobacteria, we identified two loci that affect the ability of M. marinum to infect macrophages, designated mel(1) and mel(2). In silico analyses of the 11 putative genes in these loci suggest that mel(1) encodes secreted proteins that include a putative membrane protein and two putative transglutaminases, whereas mel(2) is involved in secondary metabolism or biosynthesis of fatty acids. Interestingly, mel(2) is unique to M. marinum and the M. tuberculosis complex and not present in any other sequenced mycobacterial species. M. marinum mutants with mutations in mel(1) and mel(2), constructed by allelic exchange, are defective in the ability to infect both murine and fish macrophage cell lines. These data suggest that the genes in mel(1) and mel(2) are important for the ability of M. marinum to infect host cells.
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Registered trials
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