ArticleInfection and immunity2004
The major histocompatibility complex haplotype affects T-cell recognition of mycobacterial antigens but not resistance to Mycobacterium tuberculosis in C3H mice.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis in genetically diverse mice.PLoS pathogens · 2024Article
- Histopathological Analysis ofPolish journal of microbiology · 2021Article
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- Evaluation of an outbred mouse model for Francisella tularensis vaccine development and testing.PloS one · 2018Article
- Lactation-Based Maternal Educational Immunity Crosses MHC Class I Barriers and Can Impart Th1 Immunity to Th2-Biased Recipients.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection.Scientific reports · 2016Article
- Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies.Seminars in immunopathology · 2016Review
- TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection.PLoS pathogens · 2016Article
- The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.PLoS genetics · 2015Article
- In search of a new paradigm for protective immunity to TB.Nature reviews. Microbiology · 2014Review
- Article
- CBA/J mice generate protective immunity to soluble Ag85 but fail to respond efficiently to Ag85 during natural Mycobacterium tuberculosis infection.European journal of immunology · 2012Article
- Mycobacterium tuberculosis directs immunofocusing of CD8+ T cell responses despite vaccination.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- H-2 alleles contribute to antigen 85-specific interferon-gamma responses during Mycobacterium tuberculosis infection.Cellular immunology · 2011Article
- Dominant role of the sst1 locus in pathogenesis of necrotizing lung granulomas during chronic tuberculosis infection and reactivation in genetically resistant hosts.The American journal of pathology · 2009Article
- Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10.Infection and immunity · 2008Article
- Antigen-specific CD8+ T cells and the development of central memory during Mycobacterium tuberculosis infection.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Genetic architecture of tuberculosis resistance in a mouse model of infection.Genes and immunity · 2006Article
- Progress and new directions in genetics of tuberculosis: an NHLBI working group report.American journal of respiratory and critical care medicine · 2005Article
- Anamnestic responses of mice following Mycobacterium tuberculosis infection.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Both innate and adaptive immunity play an important role in host resistance to Mycobacterium tuberculosis infection. Although several studies have suggested that the major histocompatibility complex (MHC) haplotype affects susceptibility to infection, it remains unclear whether the modulation of T-cell immunity by the MHC locus determines the host's susceptibility to tuberculosis. To determine whether allelic differences in the MHC locus affect the T-cell immune response after M. tuberculosis infection, we infected inbred and H-2 congenic mouse strains by the respiratory route. The H-2 locus has a profound effect on the antigen-specific CD4+-T-cell response after M. tuberculosis infection. CD4+ T cells from infected mice of the H-2(b) haplotype produced more gamma interferon (IFN-gamma) after in vitro stimulation with mycobacterial antigens than mice of the H-2(k) haplotype. A higher level of IFN-gamma was also detected in bronchoalveolar lavage fluid from infected mice of the H-2(b) haplotype. Furthermore, C3.SW-H2(b)/SnJ mice generate and recruit activated T cells to the lung after infection. Despite a robust immune response, C3.SW-H2(b)/SnJ mice succumbed to infection early and were similarly susceptible to infection as other C3H (H-2(k)) substrains. These results suggest that although the MHC haplotype has a profound impact on the T-cell recognition of M. tuberculosis antigens, the susceptibility of C3H mice to infection is MHC independent.
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Registered trials
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