ArticleThe Journal of experimental medicine2004
Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection.
Article in The Journal of experimental medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 118 citations in OpenAlex.
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- Immunogenicity and protection against Mycobacterium avium with a heterologous RNA prime and protein boost vaccine regimen.Tuberculosis (Edinburgh, Scotland) · 2023Article
- Evaluating the Performance of PPE44, HSPX, ESAT-6 and CFP-10 Factors in Tuberculosis Subunit Vaccines.Current microbiology · 2022Review
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- Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion.The Journal of experimental medicine · 2022Article
- It Takes a Village: The Multifaceted Immune Response toFrontiers in immunology · 2022Review
- A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.PLoS pathogens · 2020Article
- Diminished Frequencies of Cytotoxic Marker Expressing T- and NK Cells at the Site ofFrontiers in immunology · 2020Article
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- An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice.NPJ vaccines · 2019Article
- Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors.Cell reports · 2018Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Optimum immunity against Mycobacterium tuberculosis requires both CD4(+) and CD8(+) T cells. In contrast with CD4(+) T cells, few antigens are known that elicit CD8(+) T cells during infection. CD8(+) T cells specific for culture filtrate protein-10 (CFP10) are found in purified protein derivative positive donors, suggesting that CFP10 primes CD8(+) T cells in vivo. Using T cells from M. tuberculosis-infected mice, we identified CFP10 epitopes recognized by CD8(+) T cells and CD4(+) T cells. CFP10-specific T cells were detected as early as week 3 after infection and at their peak accounted for up to 30% of CD8(+) T cells in the lung. IFNgamma-producing CD8(+) and CD4(+) T cells recognizing CFP10 epitopes were preferentially recruited to the lungs of M. tuberculosis-infected mice. In vivo cytolytic activity of CD8(+) T cells specific for CFP10 and TB10.3/10.4 proteins was detected in the spleen, pulmonary lymph nodes, and lungs of infected mice. The cytolytic activity persisted long term and could be detected 260 d after infection. This paper highlights the cytolytic function of antigen-specific CD8(+) T cells elicited by M. tuberculosis infection and demonstrates that large numbers of CFP10-specific cytolytic CD8(+) T cells are recruited to the lung after M. tuberculosis infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.