ArticleBiophysical journal2005
Force history dependence of receptor-ligand dissociation.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 126 citations in OpenAlex.
- Different Cell Wall Compositions of ESKAPE Isolates on Glass Surfaces Impact Adhesion Adaptability to Dynamic Shear Stress.Microorganisms · 2026Article
- Mechanotransduction through T cell receptors: consensus, controversies and future outlooks.Experimental & molecular medicine · 2026Review
- Receptor-Ligand Binding: Effect of Mechanical Factors.International journal of molecular sciences · 2023Review
- Immune-mediated alopecias and their mechanobiological aspects.Cells & development · 2022Review
- Mechanotransduction as a major driver of cell behaviour: mechanisms, and relevance to cell organization and future research.Open biology · 2021Review
- Analysing the Initial Bacterial Adhesion to Evaluate the Performance of Antifouling Surfaces.Antibiotics (Basel, Switzerland) · 2020Article
- Dynamic bonds and their roles in mechanosensing.Current opinion in chemical biology · 2019Review
- Single-molecule investigations of T-cell activation.Current opinion in biomedical engineering · 2019Article
- Fast Force Loading Disrupts Molecular Binding Stability in Human and Mouse Cell Adhesions.Molecular & cellular biomechanics : MCB · 2019Article
- A model for cyclic mechanical reinforcement.Scientific reports · 2016Article
- Stiff substrates enhance monocytic cell capture through E-selectin but not P-selectin.Integrative biology : quantitative biosciences from nano to macro · 2016Article
- Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell.Journal of visualized experiments : JoVE · 2015Article
- Probing time-dependent mechanical behaviors of catch bonds based on two-state models.Scientific reports · 2015Article
- Contribution of the CR domain to P-selectin lectin domain allostery by regulating the orientation of the EGF domain.PloS one · 2015Article
- Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force.Science (New York, N.Y.) · 2014Article
- Stochastic simulation of single-molecule pulling experiments.The European physical journal. E, Soft matter · 2014Article
- Mechanochemitry: a molecular biomechanics view of mechanosensing.Annals of biomedical engineering · 2014Review
- P-fimbriae in the presence of anti-PapA antibodies: new insight of antibodies action against pathogens.Scientific reports · 2013Article
- Rupture of multiple catch-slip bonds: Two-state two-pathway catch-slip bonds.The European physical journal. E, Soft matter · 2013Article
- Biophysical description of multiple events contributing blood leukocyte arrest on endothelium.Frontiers in immunology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Receptor-ligand bonds that mediate cell adhesion are often subjected to forces that regulate their dissociation via modulating off-rates. Off-rates control how long receptor-ligand bonds last and how much force they withstand. One should therefore be able to determine off-rates from either bond lifetime or unbinding force measurements. However, substantial discrepancies exist between the force dependence of off-rates derived from the two types of measurements even for the same interactions, e.g., selectins dissociating from their ligands, which mediate the tethering and rolling of leukocytes on vascular surfaces during inflammation and immune surveillance. We used atomic force microscopy to measure survival times of P-selectin dissociating from P-selectin glycoprotein ligand 1 or from an antibody in both bond lifetime and unbinding force experiments. By a new method of data analysis, we showed that the discrepancies resulted from the assumption that off-rates were functions of force only. The off-rates derived from forced dissociation data depended not only on force but also on the history of force application. This finding provides a new paradigm for understanding how force regulates receptor-ligand interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.