ArticleMolecular and cellular neurosciences2004
Temporally distinct demands for classic cadherins in synapse formation and maturation.
Article in Molecular and cellular neurosciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Genome-wide association scan of trait depression.Biological psychiatry · 2010Pooled it
- Regulation of Presynaptic Release Machinery by Cell Adhesion Molecules.Advances in neurobiology · 2023Article
- Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling.BMC biology · 2021Article
- Synaptic recognition molecules in development and disease.Current topics in developmental biology · 2021Article
- The Cadherin Superfamily in Neural Circuit Assembly.Cold Spring Harbor perspectives in biology · 2018Review
- Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation.Frontiers in molecular neuroscience · 2018Article
- Pathophysiology of Trans-Synaptic Adhesion Molecules: Implications for Epilepsy.Frontiers in cell and developmental biology · 2018Review
- Release activity-dependent control of vesicle endocytosis by the synaptic adhesion molecule N-cadherin.Scientific reports · 2017Article
- Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.Scientific reports · 2016Article
- Temporal patterns of gene expression during calyx of held development.Developmental neurobiology · 2016Article
- Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation.eLife · 2015Article
- Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits.The Journal of comparative neurology · 2015Article
- The classic cadherins in synaptic specificity.Cell adhesion & migration · 2015Review
- Cadherin-based transsynaptic networks in establishing and modifying neural connectivity.Current topics in developmental biology · 2015Review
- N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo.Hippocampus · 2014Article
- Adaptation of short-term plasticity parameters via error-driven learning may explain the correlation between activity-dependent synaptic properties, connectivity motifs and target specificity.Frontiers in computational neuroscience · 2014Article
- Target-cell-specific short-term plasticity in local circuits.Frontiers in synaptic neuroscience · 2013Review
- Late recruitment of synapsin to nascent synapses is regulated by Cdk5.Cell reports · 2013Article
- N-cadherin relocalizes from the periphery to the center of the synapse after transient synaptic stimulation in hippocampal neurons.PloS one · 2013Article
- Asymmetric N-cadherin expression results in synapse dysfunction, synapse elimination, and axon retraction in cultured mouse neurons.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Classic cadherins are synaptic adhesion proteins that have been implicated in synapse formation and targeting. Brief inactivation of classic cadherin function in young neurons appears to abrogate synapse formation when examined acutely. It remains unknown if such abrogation is unique to young neurons, whether it occurs by stalling neuronal maturation or by directly interfering with the process of synapse assembly, or whether synapse targeting is altered. Here we asked if sustained pan-cadherin blockade would prevent or alter the progression of axonal and dendritic outgrowth, synaptogenesis, or the stereotypic distribution of excitatory and inhibitory synapses on cultured hippocampal neurons. While pre- and postsynaptic cadherins are required for synapse assembly in young neurons, we find that in neurons older than 10 days, classic cadherins are entirely dispensable for joining and aligning presynaptic vesicle clusters with molecular markers of the postsynaptic density. Furthermore, we find that the proportion and relative distributions of excitatory and inhibitory terminals on single neurons are not altered. However, synapses that form on neurons in which cadherin function is blocked are smaller; they exhibit decreased synaptic vesicle recycling and a decreased frequency of spontaneous EPSCs. Moreover, they fail to acquire resistance to F-actin depolymerization, a hallmark of mature, stable contacts. These data provide new evidence that cadherins are required to promote synapse stabilization and structural and functional maturation, but dispensable for the correct subcellular distribution of excitatory and inhibitory synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.