SynthesisHealth and quality of life outcomes2004
The measurement of health-related quality of life (QOL) in paediatric clinical trials: a systematic review.
Synthesis in Health and quality of life outcomes, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 7 syntheses or guidelines pooled it, 203 citations in OpenAlex.
- Taking stock of psychosocial rehabilitation in children and adolescents: a systematic review with meta-analysis.Frontiers in rehabilitation sciences · 2025Pooled it
- A comprehensive systematic review of health-related quality of life measures in short stature paediatric patients.Endocrine · 2024Pooled it
- Pooled it
- Quality of life in children with adverse drug reactions: a narrative and systematic review.British journal of clinical pharmacology · 2015Pooled it
- Amblyopia and quality of life: a systematic review.Eye (London, England) · 2011Pooled it
- Measuring health-related quality of life in drug clinical trials: is it given due importance?Pharmacy world & science : PWS · 2008Pooled it
- Long-acting medications for the hyperkinetic disorders. A systematic review and European treatment guideline.European child & adolescent psychiatry · 2006Guideline
- Health-related quality of life in children and adolescents with paediatric acquired brain injury: Secondary data analysis from a randomised controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Trial
- Implementation of the Kids-CAT in clinical settings: a newly developed computer-adaptive test to facilitate the assessment of patient-reported outcomes of children and adolescents in clinical practice in Germany.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Trial
- A first-year dornase alfa treatment impact on clinical parameters of patients with cystic fibrosis: the Brazilian cystic fibrosis multicenter study.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2013Trial
- Changes in self-reported and parent-reported health-related quality of life in overweight children and adolescents participating in an outpatient training: findings from a 12-month follow-up study.Health and quality of life outcomes · 2013Trial
- Atomoxetine improves patient and family coping in attention deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled study in Swedish children and adolescents.European child & adolescent psychiatry · 2009Trial
- The development of the ScoPeO-Kids: A new measure of quality of life for children living in contexts of vulnerability.PLOS global public health · 2026Article
- Assessment of Health-Related Quality of Life Among Palestinian Adolescents With Type 1 Diabetes: A Cross-Sectional Investigation.Pediatric diabetes · 2025Article
- The Impact of Cost of Living on the Quality of Life of Cystic Fibrosis Patients: A Study in Greece.Cureus · 2024Article
- Cost-Effectiveness of Blinatumomab in Pediatric Patients with High-Risk First-Relapse B-Cell Precursor Acute Lymphoblastic Leukemia in France.PharmacoEconomics - open · 2023Article
- Parents' Perceptions of the Effectiveness of Music Therapy on Their Chronically Ill Children.Behavioral sciences (Basel, Switzerland) · 2023Article
- Quality of Life (QoL) of Children and Adolescents Participating in a Precision Medicine Trial for High-Risk Childhood Cancer.Cancers · 2022Article
- Sequential Multiple Imputation for Real-World Health-Related Quality of Life Missing Data after Bariatric Surgery.International journal of environmental research and public health · 2022Article
- Health-related quality of life in 4-to-6-year-old children with type 1 diabetes mellitus estimated by children and their mothers.European journal of pediatrics · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe goal of much care in chronic childhood illness is to improve quality of life (QOL). However, surveys suggest QOL measures are not routinely included. In addition, there is little consensus about the quality of many QOL measures.
objectivesTo determine the extent to which quality of life (QOL) measures are used in paediatric clinical trials and evaluate the quality of measures used.
designSystematic literature review. REVIEW
methodsIncluded paediatric trials published in English between 1994 and 2003 involving children and adolescents up to the age of 20 years, and use of a standardised QOL measure. Data Sources included MEDLINE, CINAHL, EMB Reviews, AMED, BNI, PSYCHINFO, the Cochrane library, Internet, and reference lists from review articles.
resultsWe identified 18 trials including assessment of QOL (4 Asthma, 4 Rhinitis, 2 Dermatitis, and single studies of Eczema, Cystic fibrosis, Otis media, Amblyopia, Diabetes, Obesity associated with a brain tumour, Idiopathic short stature, and Congenital agranulocytosis). In three trials, parents rated their own QOL but not their child's. Fourteen different QOL measures were used but only two fulfilled our minimal defined criteria for quality.
conclusionsThis review confirms previous reports of limited use of QOL measures in paediatric clinical trials. Our review provides information about availability and quality of measures which will be of especial value to trial developers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.