ArticleBMC cell biology2004
The architecture of chicken chromosome territories changes during differentiation.
Article in BMC cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 64 citations in OpenAlex.
- A new emu genome illuminates the evolution of genome configuration and nuclear architecture of avian chromosomes.Genome research · 2021Article
- Radial Organization in the Mammalian Nucleus.Frontiers in genetics · 2020Review
- Chromosome positioning in interphase nuclei of hematopoietic stem cell and myeloid precursor.Hematology reports · 2018Article
- Transcription-dependent radial distribution of TCF7L2 regulated genes in chromosome territories.Chromosoma · 2017Article
- Nuclear morphologies: their diversity and functional relevance.Chromosoma · 2017Review
- Topologically associated domains enriched for lineage-specific genes reveal expression-dependent nuclear topologies during myogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Spatial distribution of centromeres and telomeres at interphase varies among Brachypodium species.Journal of experimental botany · 2015Article
- Nuclear accessibility of β-actin mRNA is measured by 3D single-molecule real-time tracking.The Journal of cell biology · 2015Article
- Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery.Genome biology · 2013Article
- The changes in chromosome 6 spatial organization during chromatin polytenization in the Calliphora erythrocephala Mg. (Diptera: Calliphoridae) nurse cells.Protoplasma · 2013Article
- The radial nuclear positioning of genes correlates with features of megabase-sized chromatin domains.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Condensin II promotes the formation of chromosome territories by inducing axial compaction of polyploid interphase chromosomes.PLoS genetics · 2012Article
- Article
- Nuclei of chicken neurons in tissues and three-dimensional cell cultures are organized into distinct radial zones.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- Statistical analysis of 3D images detects regular spatial distributions of centromeres and chromocenters in animal and plant nuclei.PLoS computational biology · 2010Article
- Epigenetic modifications in 3D: nuclear organization of the differentiating mammary epithelial cell.Journal of mammary gland biology and neoplasia · 2010Review
- Review
- 3D fluorescent in situ hybridization using Arabidopsis leaf cryosections and isolated nuclei.Plant methods · 2009Article
- Nuclear architecture of resting and LPS-stimulated porcine neutrophils by 3D FISH.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- Three-dimensional positioning of genes in mouse cell nuclei.Chromosoma · 2008Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBetween cell divisions the chromatin fiber of each chromosome is restricted to a subvolume of the interphase cell nucleus called chromosome territory. The internal organization of these chromosome territories is still largely unknown.
resultsWe compared the large-scale chromatin structure of chromosome territories between several hematopoietic chicken cell types at various differentiation stages. Chromosome territories were labeled by fluorescence in situ hybridization in structurally preserved nuclei, recorded by confocal microscopy and evaluated visually and by quantitative image analysis. Chromosome territories in multipotent myeloid precursor cells appeared homogeneously stained and compact. The inactive lysozyme gene as well as the centromere of the lysozyme gene harboring chromosome located to the interior of the chromosome territory. In further differentiated cell types such as myeloblasts, macrophages and erythroblasts chromosome territories appeared increasingly diffuse, disaggregating to separable substructures. The lysozyme gene, which is gradually activated during the differentiation to activated macrophages, as well as the centromere were relocated increasingly to more external positions.
conclusionsOur results reveal a cell type specific constitution of chromosome territories. The data suggest that a repositioning of chromosomal loci during differentiation may be a consequence of general changes in chromosome territory morphology, not necessarily related to transcriptional changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.