ReviewImmunology2004
Regulation of T-cell receptor signalling by membrane microdomains.
Review in Immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 96 citations in OpenAlex.
- Article
- A sensitive S-Trap-based approach to the analysis of T cell lipid raft proteome.Journal of lipid research · 2020Article
- ASGR1 and Its Enigmatic Relative, CLEC10A.International journal of molecular sciences · 2020Review
- Toward a Membrane-Centric Biology.Frontiers in immunology · 2020Article
- Synthesis and evaluation of new amidrazone-derived hydrazides as a potential anti-inflammatory agents.Monatshefte fur chemie · 2018Article
- The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response.Mediators of inflammation · 2018Review
- Acid sphingomyelinase mediates human CD4Cell death & disease · 2017Review
- Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses.Cell death & disease · 2015Article
- Caveolins in cardioprotection - translatability and mechanisms.British journal of pharmacology · 2015Review
- Leishmania donovani infection enhances lateral mobility of macrophage membrane protein which is reversed by liposomal cholesterol.PLoS neglected tropical diseases · 2014Article
- Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly.Cell communication and signaling : CCS · 2014Article
- Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?British journal of clinical pharmacology · 2013Article
- T cells from indolent CLL patients prevent apoptosis of leukemic B cells in vitro and have altered gene expression profile.Cancer immunology, immunotherapy : CII · 2013Article
- Combined fish oil and astaxanthin supplementation modulates rat lymphocyte function.European journal of nutrition · 2012Article
- Impact of fatty acid status on immune function of children in low-income countries.Maternal & child nutrition · 2011Review
- Proteomic approaches to understanding the role of the cytoskeleton in host-defense mechanisms.Expert review of proteomics · 2011Review
- Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules.PloS one · 2011Article
- Article
- Involvement of HAb18G/CD147 in T cell activation and immunological synapse formation.Journal of cellular and molecular medicine · 2010Article
- Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
There is now considerable evidence suggesting that the plasma membrane of mammalian cells is compartmentalized by functional lipid raft microdomains. These structures are assemblies of specialized lipids and proteins and have been implicated in diverse biological functions. Analysis of their protein content using proteomics and other methods revealed enrichment of signalling proteins, suggesting a role for these domains in intracellular signalling. In T lymphocytes, structure/function experiments and complementary pharmacological studies have shown that raft microdomains control the localization and function of proteins which are components of signalling pathways regulated by the T-cell antigen receptor (TCR). Based on these studies, a model for TCR phosphorylation in lipid rafts is presented. However, despite substantial progress in the field, critical questions remain. For example, it is unclear if membrane rafts represent a homogeneous population and if their structure is modified upon TCR stimulation. In the future, proteomics and the parallel development of complementary analytical methods will undoubtedly contribute in further delineating the role of lipid rafts in signal transduction mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.