ArticleClinical & experimental metastasis2004
Marrow-derived mesenchymal stem cells: role in epithelial tumor cell determination.
Article in Clinical & experimental metastasis, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review.Stem cell research & therapy · 2018Pooled it
- Mesenchymal stromal cells as cancer promoters.Oncogene · 2024Review
- Bio-distribution and toxicity potential of human umbilical cord mesenchymal stem cells in cynomolgus monkeys.Scientific reports · 2024Article
- STEAP1-4 (Six-Transmembrane Epithelial Antigen of the Prostate 1-4) and Their Clinical Implications for Prostate Cancer.Cancers · 2022Review
- Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine.Current diabetes reports · 2020Review
- In vivo Monitoring and Assessment of Exogenous Mesenchymal Stem Cell-Derived Exosomes in Mice with Ischemic Stroke by Molecular Imaging.International journal of nanomedicine · 2020Article
- Human mesenchymal stem cells promote tumor growth via MAPK pathway and metastasis by epithelial mesenchymal transition and integrin α5 in hepatocellular carcinoma.Cell death & disease · 2019Article
- Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma:World journal of gastroenterology · 2019Article
- Interactions of human MSC with head and neck squamous cell carcinoma cell line PCI-13 reduce markers of epithelia-mesenchymal transition.Clinical oral investigations · 2015Article
- Influence of mesenchymal stem cells on metastasis development in mice in vivo.Stem cell research & therapy · 2015Article
- Aromatase expression increases the survival and malignancy of estrogen receptor positive breast cancer cells.PloS one · 2015Article
- The role of adipose-derived stem cells in breast cancer progression and metastasis.Stem cells international · 2015Review
- Asymmetric segregation of template DNA strands in basal-like human breast cancer cell lines.Molecular cancer · 2013Article
- Comparison of breast and abdominal adipose tissue mesenchymal stromal/stem cells in support of proliferation of breast cancer cells.Cancer investigation · 2013Article
- Behaviour of mesenchymal stem cells from bone marrow of untreated advanced breast and lung cancer patients without bone osteolytic metastasis.Clinical & experimental metastasis · 2013Article
- Mesenchymal stem cells develop tumor tropism but do not accelerate breast cancer tumorigenesis in a somatic mouse breast cancer model.PloS one · 2013Article
- hMSCs possess the potential to differentiate into DP cells in vivo and in vitro.Cell biology international reports · 2012Article
- Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97-H cell line.Cancer science · 2010Article
- Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk.Molecular cancer · 2010Article
- Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independence.Breast cancer research and treatment · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marrow stroma represents an advantageous environment for development of micrometastatic cells. Within the cellular structure of marrow stroma, mesenchymal stem cells (MSC) have been postulated as an interacting target for disseminated cancer cells. The studies reported here were performed to gain more information on the interaction of the human breast cancer cell line MCF-7 with human bone marrow-derived MSC cells and to investigate whether this interaction affects tumor cell properties. The results showed that after co-culture with MSC, changes were detected in the morphology, proliferative capacity and aggregation pattern of MCF-7 cells, but these parameters were not affected after the co-culture of MSC cells with a non-tumorigenic breast epithelial cell line, MCF-10. Since the indirect culture of MCF-7 with MSC or its products also resulted in functional changes in the tumor cells, we evaluated whether these effects could be attributed to growth factors produced by MSC cells. It was found that VEGF and IL-6 mimic the effects produced by MSC or its products on the proliferation and aggregation properties of MCF-7, cells, respectively. Thus, it seems that after entry of disseminated tumor cells into the marrow space, their proliferative and morphogenetic organization patterns are modified after interaction with distinct stromal cells and/or with specific signals from the marrow microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.