ArticleLipids2004
Incorporation of n-3 fatty acids into plasma and liver lipids of rats: importance of background dietary fat.
Article in Lipids, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Effects of dietary saturated and n-6 polyunsaturated fatty acids on the incorporation of long-chain n-3 polyunsaturated fatty acids into blood lipids.European journal of clinical nutrition · 2016Trial
- Trial
- Krill oil extract suppresses the proliferation of colorectal cancer cells through activation of caspase 3/9.Nutrition & metabolism · 2019Article
- 17β-estradiol increases liver and serum docosahexaenoic acid in mice fed varying levels of α-linolenic acid.Lipids · 2014Article
- Article
- Article
- Consumption of an n-3 polyunsaturated fatty acid-enriched dip modulates plasma lipid profile in subjects with diabetes type II.European journal of clinical nutrition · 2007Article
- Dietary alpha-linolenic acid increases brain but not heart and liver docosahexaenoic acid levels.Lipids · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The health benefits of long-chain n-3 PUFA (20:5n-3 and 22:6n-3) depend on the extent of incorporation of these FA into plasma and tissue lipids. This study aimed to investigate the effect of the background dietary fat (saturated, monounsaturated, or n-6 polyunsaturated) on the quantitative incorporation of dietary 18:3n-3 and its elongated and desaturated products into the plasma and the liver lipids of rats. Female weanling Wistar rats (n = 54) were randomly assigned to six diet groups (n = 9). The fat added to the semipurified diets was tallow (SFA), tallow plus linseed oil (SFA-LNA), sunola oil (MUFA), sunola oil plus linseed oil (MUFA-LNA), sunflower oil (PUFA), or sunflower oil plus linseed oil (PUFA-LNA). At the completion of the 4-wk feeding period, quantitative FA analysis of the liver and plasma was undertaken by GC. The inclusion of linseed oil in the rat diets increased the level of 18:3n-3, 20:5n-3, and, to a smaller degree, 22:6n-3 in plasma and liver lipids regardless of the background dietary fat. The extent of incorporation of 18:3n-3, 20:5n-3, and 22:5n-3 followed the order SFA-LNA > MUFA-LNA > PUFA-LNA. Levels of 22:6n-3 were increased to a similar extent regardless of the type of major fat in the rat diets. This indicates that the background diet affects the incorporation in liver and plasma FA pools of the n-3 PUFA with the exception of 22:6n-3 and therefore the background diet has the potential to influence the already established health benefits of long-chain n-3 fatty acids.
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