ArticleJournal of molecular evolution2004
Modulation of base-specific mutation and recombination rates enables functional adaptation within the context of the genetic code.
Article in Journal of molecular evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Amino acid alphabet size in protein evolution experiments: better to search a small library thoroughly or a large library sparsely?Protein engineering, design & selection : PEDS · 2008Article
- An efficient visualization tool for the analysis of protein mutation matrices.BMC bioinformatics · 2008Article
- Evolvability is a selectable trait.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Microarray and EST database estimates of mRNA expression levels differ: the protein length versus expression curve for C. elegans.BMC genomics · 2004Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The persistence of life requires populations to adapt at a rate commensurate with the dynamics of their environment. Successful populations that inhabit highly variable environments have evolved mechanisms to increase the likelihood of successful adaptation. We introduce a 64 x 64 matrix to quantify base-specific mutation potential, analyzing four different replicative systems, error-prone PCR, mouse antibodies, a nematode, and Drosophila. Mutational tendencies are correlated with the structural evolution of proteins. In systems under strong selective pressure, mutational biases are shown to favor the adaptive search of space, either by base mutation or by recombination. Such adaptability is discussed within the context of the genetic code at the levels of replication and codon usage.
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