ArticleCurrent genetics2005
The yeast VPS genes affect telomere length regulation.
Article in Current genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Telomeres and Telomere Length: A General Overview.Cancers · 2020Review
- Genome-wide identification for genes involved in sodium dodecyl sulfate toxicity in Saccharomyces cerevisiae.BMC microbiology · 2020Article
- Genetic variations associated with telomere length confer risk of gastric cardia adenocarcinoma.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019Article
- Article
- Cis and trans interactions between genes encoding PAF1 complex and ESCRT machinery components in yeast.Current genetics · 2018Article
- Article
- microRNAs' differential regulations mediate the progress of Human Papillomavirus (HPV)-induced Cervical Intraepithelial Neoplasia (CIN).BMC systems biology · 2015Article
- Article
- Genome-wide studies of telomere biology in budding yeast.Microbial cell (Graz, Austria) · 2014Review
- Nature vs nurture: interplay between the genetic control of telomere length and environmental factors.Cell cycle (Georgetown, Tex.) · 2013Article
- Environmental stresses disrupt telomere length homeostasis.PLoS genetics · 2013Article
- The genetics and clinical manifestations of telomere biology disorders.Genetics in medicine : official journal of the American College of Medical Genetics · 2010Review
- The association of telomere length and genetic variation in telomere biology genes.Human mutation · 2010Article
- Article
- A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length.Journal of medical genetics · 2009Article
- A genome-wide screen for essential yeast genes that affect telomere length maintenance.Nucleic acids research · 2009Article
- Functional annotations for the Saccharomyces cerevisiae genome: the knowns and the known unknowns.Trends in microbiology · 2009Review
- Article
- A Trypanosoma cruzi phosphatidylinositol 3-kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis.The Journal of biological chemistry · 2008Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic cells invest a large proportion of their genome in maintaining telomere length homeostasis. Among the 173 non-essential yeast genes found to affect telomere length, a large proportion is involved in vacuolar traffic. When mutated, these vacuolar protein-sorting (VPS) genes lead to telomeres shorter than those observed in the wild type. Using genetic analysis, we characterized the pathway by which VPS15, VPS34, VPS22, VPS23 and VPS28 affect the telomeres. Our results indicate that these VPS genes affect telomere length through a single pathway and that this effect requires the activity of telomerase and the Ku heterodimer, but not the activity of Tel1p or Rif2p. We present models to explain the link between vacuolar traffic and telomere length homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.