ArticlePsychopharmacology2005
Angiotensin II blocks memory consolidation through an AT2 receptor-dependent mechanism.
Article in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies.Neuroscience and biobehavioral reviews · 2018Pooled it
- Cognitive enhancement following acute losartan in normotensive young adults.Psychopharmacology · 2011Trial
- Sex-Dependent Effects of Angiotensin Type 2 Receptor-Expressing Medial Prefrontal Cortex Interneurons in Fear Extinction Learning.Biological psychiatry global open science · 2024Article
- On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory.Frontiers in behavioral neuroscience · 2022Article
- Facilitation of TRKB Activation by the Angiotensin II Receptor Type-2 (AT2R) Agonist C21.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Evaluation of an angiotensin Type 1 receptor blocker on the reconsolidation of fear memory.Translational psychiatry · 2020Article
- Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats.Neurotoxicity research · 2020Article
- How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis.Frontiers in psychiatry · 2020Article
- Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice Phenotype Characterization.Biomolecules · 2019Article
- Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair.Frontiers in aging neuroscience · 2017Article
- Brain Renin-Angiotensin System and Microglial Polarization: Implications for Aging and Neurodegeneration.Frontiers in aging neuroscience · 2017Review
- Cross-Generational trans Fat Consumption Favors Self-Administration of Amphetamine and Changes Molecular Expressions of BDNF, DAT, and D1/D2 Receptors in the Cortex and Hippocampus of Rats.Neurotoxicity research · 2015Article
- Angiotensin type 1a receptors on corticotropin-releasing factor neurons contribute to the expression of conditioned fear.Genes, brain, and behavior · 2015Article
- Dopamine Receptors and Neurodegeneration.Aging and disease · 2015Review
- Angiotensin type 1 receptor inhibition enhances the extinction of fear memory.Biological psychiatry · 2014Article
- Brain renin-angiotensin system and dopaminergic cell vulnerability.Frontiers in neuroanatomy · 2014Review
- The effects of losartan on memory performance and leptin resistance induced by obesity and high-fat diet in adult male rats.Iranian journal of basic medical sciences · 2014Article
- Angiotensin II's role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: amygdalar angiotensin receptors and panic.Progress in neuro-psychopharmacology & biological psychiatry · 2013Article
- Effect of angiotensin II on spatial memory, cerebral blood flow, cholinergic neurotransmission, and brain derived neurotrophic factor in rats.Psychopharmacology · 2013Article
- Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment.Radiation research · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE AND
objectivesSeveral studies suggest that the brain renin-angiotensin system is involved in memory consolidation. However, the participation of angiotensin II (AII) in this process is controversial. This is probably due to the fact that many of the studies carried out to elucidate this matter employed multitrial learning paradigms together with pretraining intracerebroventricular infusions, and therefore were unable to distinguish between consolidation and retrieval related events and lacked anatomical specificity. To circumvent this problem, we analyzed the role played in memory consolidation by AII using the hippocampal-dependent, one-trial, step-down inhibitory avoidance task (IA) in combination with stereotaxically localized intrahippocampal infusion of drugs. METHODS AND
resultsRats bilaterally implanted with infusion cannulae into the CA1 region of the dorsal hippocampus (CA1) were trained in IA and tested for memory retention 24 h later. We found that when infused into CA1 immediately or 30 min after training but not later, AII produced a dose-dependent amnesic effect without altering locomotor activity, exploratory behavior or anxiety state. The amnesic effect of AII was not mimicked by angiotensin IV (AIV) and was totally blocked by the AII-type 2 receptor (AT2) antagonist, PD123319, but not by the AII-type 1 receptor (AT1) antagonist, losartan. Importantly, when infused alone, neither PD123319 nor losartan produced any effect on memory retention.
conclusionsOur data indicate that, when given into CA1, AII blocks memory formation through a mechanism involving activation of AT2 receptors; however, endogenous AII does not seem to participate in the consolidation of IA long-term memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.