ArticlePLoS biology2004
Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors.
Article in PLoS biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 64 citations in OpenAlex.
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- The Stage-Based Model of Addiction-UsingInternational journal of molecular sciences · 2023Review
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- Interactions between the microbiome and mating influence the female's transcriptional profile in Drosophila melanogaster.Scientific reports · 2020Article
- Flying Together:International journal of molecular sciences · 2020Review
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- Candidate genes for cooperation and aggression in the social wasp Polistes dominula.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- A Fly's Eye View of Natural and Drug Reward.Frontiers in physiology · 2018Review
- High Throughput Measurement of Locomotor Sensitization to Volatilized Cocaine inFrontiers in molecular neuroscience · 2018Article
- Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep.PLoS genetics · 2017Article
- Genetics and genomics of alcohol responses in Drosophila.Neuropharmacology · 2017Review
- Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function.PLoS genetics · 2017Article
- Review
- Using In Vitro Electrophysiology to Screen Medications: Accumbal Plasticity as an Engram of Alcohol Dependence.International review of neurobiology · 2016Article
- Peer Influence, Genetic Propensity, and Binge Drinking: A Natural Experiment and a Replication.AJS; American journal of sociology · 2015Article
- Comparative brain transcriptomic analyses of scouting across distinct behavioural and ecological contexts in honeybees.Proceedings. Biological sciences · 2014Article
- Increased behavioral responses to ethanol in Lmo3 knockout mice.Genes, brain, and behavior · 2014Article
- Beadex function in the motor neurons is essential for female reproduction in Drosophila melanogaster.PloS one · 2014Article
- The novel gene tank, a tumor suppressor homolog, regulates ethanol sensitivity in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Drosophila melanogaster as a model to study drug addiction.Human genetics · 2012Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Drosophila has been developed recently as a model system to investigate the molecular and neural mechanisms underlying responses to drugs of abuse. Genetic screens for mutants with altered drug-induced behaviors thus provide an unbiased approach to define novel molecules involved in the process. We identified mutations in the Drosophila LIM-only (LMO) gene, encoding a regulator of LIM-homeodomain proteins, in a genetic screen for mutants with altered cocaine sensitivity. Reduced Lmo function increases behavioral responses to cocaine, while Lmo overexpression causes the opposite effect, reduced cocaine responsiveness. Expression of Lmo in the principal Drosophila circadian pacemaker cells, the PDF-expressing ventral lateral neurons (LN(v)s), is sufficient to confer normal cocaine sensitivity. Consistent with a role for Lmo in LN(v)function,Lmomutants also show defects in circadian rhythms of behavior. However, the role for LN(v)s in modulating cocaine responses is separable from their role as pacemaker neurons: ablation or functional silencing of the LN(v)s reduces cocaine sensitivity, while loss of the principal circadian neurotransmitter PDF has no effect. Together, these results reveal a novel role for Lmo in modulating acute cocaine sensitivity and circadian locomotor rhythmicity, and add to growing evidence that these behaviors are regulated by shared molecular mechanisms. The finding that the degree of cocaine responsiveness is controlled by the Drosophila pacemaker neurons provides a neuroanatomical basis for this overlap. We propose that Lmo controls the responsiveness of LN(v)s to cocaine, which in turn regulate the flies' behavioral sensitivity to the drug.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.