ArticlePLoS biology2004
A chemoattractant role for NT-3 in proprioceptive axon guidance.
Article in PLoS biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 65 citations in OpenAlex.
- A sequential multimodal framework for spinal cord regeneration.Frontiers in cellular neuroscience · 2026Article
- Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injury.eLife · 2024Article
- Innervation in organogenesis.Current topics in developmental biology · 2022Article
- In Pursuit of an Allosteric Human Tropomyosin Kinase A (ACS medicinal chemistry letters · 2021Article
- Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3The Journal of comparative neurology · 2019Article
- NT-3/TrkC Axis Contributes to the Perineural Invasion and the Poor Prognosis in Human Salivary Adenoid Cystic Carcinoma.Journal of Cancer · 2019Article
- A Comparative Animal Study of Tendon Grafts Healing After Remnant-Preserving Versus Conventional Anterior Cruciate Ligament Reconstruction.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- NT-3 promotes proprioceptive axon regeneration when combined with activation of the mTor intrinsic growth pathway but not with reduction of myelin extrinsic inhibitors.Experimental neurology · 2016Article
- Loss of neurotrophin-3 from smooth muscle disrupts vagal gastrointestinal afferent signaling and satiation.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.Neuron · 2013Article
- Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure.Journal of neurodevelopmental disorders · 2013Article
- Elimination of aberrant DRG circuitries in Sema3A mutant mice leads to extensive neuronal deficits.PloS one · 2013Article
- Positional differences of axon growth rates between sensory neurons encoded by Runx3.The EMBO journal · 2012Article
- Specification of neural crest into sensory neuron and melanocyte lineages.Developmental biology · 2012Review
- Activation of ezrin/radixin/moesin mediates attractive growth cone guidance through regulation of growth cone actin and adhesion receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neuroprotective changes of striatal degeneration-related gene expression by acupuncture in an MPTP mouse model of Parkinsonism: microarray analysis.Cellular and molecular neurobiology · 2011Article
- Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.PLoS genetics · 2010Article
- Cellular strategies of axonal pathfinding.Cold Spring Harbor perspectives in biology · 2010Review
- Brain-derived neurotrophic factor attracts geniculate ganglion neurites during embryonic targeting.Developmental neuroscience · 2010Article
- Smooth-muscle-specific expression of neurotrophin-3 in mouse embryonic and neonatal gastrointestinal tract.Cell and tissue research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Neurotrophin-3 (NT-3) is required for proprioceptive neuron survival. Deletion of the proapoptotic gene Bax in NT-3 knockout mice rescues these neurons and allows for examination of their axon growth in the absence of NT-3 signaling. TrkC-positive peripheral and central axons from dorsal root ganglia follow proper trajectories and arrive in close proximity to their targets but fail to innervate them. Peripherally, muscle spindles are absent and TrkC-positive axons do not enter their target muscles. Centrally, proprioceptive axons branch in ectopic regions of the spinal cord, even crossing the midline. In vitro assays reveal chemoattractant effects of NT-3 on dorsal root ganglion axons. Our results show that survival factor NT-3 acts as a short-distance axon guidance molecule for muscle sensory afferents as they approach their proper targets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.