ArticleAnnals of the rheumatic diseases2005
Reactive arthritis attributable to Shigella infection: a clinical and epidemiological nationwide study.
Article in Annals of the rheumatic diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Enteric pathogens and reactive arthritis: a systematic review of Campylobacter, salmonella and Shigella-associated reactive arthritis.Journal of health, population, and nutrition · 2013Pooled it
- Campylobacter reactive arthritis: a systematic review.Seminars in arthritis and rheumatism · 2007Pooled it
- Safety and Immunogenicity of a Candidate Bioconjugate Vaccine against Shigella flexneri 2a Administered to Healthy Adults: a Single-Blind, Randomized Phase I Study.Clinical and vaccine immunology : CVI · 2016Trial
- Evaluation of a disease specific rheumatoid arthritis self-management education program, a single group repeated measures study.BMC musculoskeletal disorders · 2015Trial
- Randomized controlled trial of adalimumab in patients with nonpsoriatic peripheral spondyloarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2015Trial
- Shigella and Guillain-Barré syndrome: Reconsidering an overlooked link.The Indian journal of medical research · 2026Review
- Metabolomics: A Viable Approach to Understand the Pathogenesis of Reactive ArthritisEndocrine, metabolic & immune disorders drug targets · 2026Review
- Article
- Mucosal signatures of pathogenic T cells in HLA-B*27+ anterior uveitis and axial spondyloarthritis.JCI insight · 2024Article
- Enteric Infection-Associated Reactive Arthritis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Ophthalmic implications of biological threat agents according to the chemical, biological, radiological, nuclear, and explosives framework.Frontiers in medicine · 2023Review
- [History of reactive arthritis. Historical milestones and future].Zeitschrift fur Rheumatologie · 2022Article
- Article
- Reactive arthritis after COVID-19: a case-based review.Rheumatology international · 2021Review
- Expanding the spectrum of reactive arthritis (ReA): classic ReA and infection-related arthritis including poststreptococcal ReA, Poncet's disease, and iBCG-induced ReA.Rheumatology international · 2021Review
- Shigella sonnei: virulence and antibiotic resistance.Archives of microbiology · 2021Review
- Article
- Reactive arthritis and other musculoskeletal symptoms associated with acquisition of diarrhoeagenicAnnals of the rheumatic diseases · 2020Article
- Cohort profile of a US military population for evaluating pre-disease and disease serological biomarkers in rheumatoid and reactive arthritis: Rationale, organization, design, and baseline characteristics.Contemporary clinical trials communications · 2020Article
- Chronic Gastrointestinal and Joint-Related Sequelae Associated with Common Foodborne Illnesses: A Scoping Review.Foodborne pathogens and disease · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo study the incidence and clinical picture of Shigella associated reactive arthritis (ReA) and the arthritogenicity of various Shigella species in the population.
methodsA questionnaire on enteric and extraintestinal, especially musculoskeletal, symptoms was sent to 278 consecutive patients with Shigella positive stool culture and to 597 controls. Analysis of self reported musculoskeletal symptoms was supplemented with clinical examination of those subjects with recent symptoms.
resultsOf the patients, 14/211 (7%) had ReA, and a further 4/211 (2%) other reactive musculoskeletal symptoms (tendonitis, enthesopathy, or bursitis). Of the 14 patients with ReA, all adults, 10 had S sonnei, three S flexneri, and one S dysenteriae infection. HLA-B27 was positive in 36% of the patients with ReA. One control subject had ReA. In the patients with Shigella infection, the odds ratio for developing ReA was 16.2 (95% confidence interval 2.1 to 123.9), p = 0.001.
conclusionsReA occurred in 7% of patients after Shigella infection, with an annual incidence of 1.3/1 000 000 in Finland. Besides S flexneri, S sonnei and S dysenteriae can also trigger ReA.
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