ArticleHistochemistry and cell biology2004
Changes in P2X3 purinoceptors in sensory ganglia of the mouse during embryonic and postnatal development.
Article in Histochemistry and cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Functional role of peripheral P2X3 receptor expression in trigeminal ganglion neurons: a microarray-based evaluation of the antagonist effect of P2X3.Purinergic signalling · 2026Article
- Short-Term Functional and Morphological Changes in the Primary Cultures of Trigeminal Ganglion Cells.Current issues in molecular biology · 2022Article
- Facial Mechanosensory Influence on Forelimb Movement in Newborn Opossums, Monodelphis domestica.PloS one · 2016Article
- Purinergic signalling during development and ageing.Purinergic signalling · 2015Review
- The role of purinergic signaling in the etiology of migraine and novel antimigraine treatment.Purinergic signalling · 2015Review
- Expression of P2X3 and P2X 5 myenteric receptors varies during the intestinal postnatal development in the guinea pig.Cellular and molecular neurobiology · 2014Article
- Ion channels and migraine.Headache · 2014Review
- Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Functional analysis of a migraine-associated TRESK K+ channel mutation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Expression of P2X5 receptors in the rat, cat, mouse and guinea pig dorsal root ganglion.Histochemistry and cell biology · 2013Article
- Melanocortin-4 receptor expression in different classes of spinal and vagal primary afferent neurons in the mouse.The Journal of comparative neurology · 2012Article
- Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura.Molecular pain · 2012Article
- Molecular and functional properties of P2X receptors--recent progress and persisting challenges.Purinergic signalling · 2012Review
- Purines as potential morphogens during embryonic development.Purinergic signalling · 2012Review
- Prenatal expression of purinergic receptor P2X3 in human dorsal root ganglion.Purinergic signalling · 2012Article
- P2X7 receptors in satellite glial cells mediate high functional expression of P2X3 receptors in immature dorsal root ganglion neurons.Molecular pain · 2012Article
- Purinergic signaling in embryonic and stem cell development.Cellular and molecular life sciences : CMLS · 2011Review
- Inhibition of ATP-induced Ca2+ influx by corticosterone in dorsal root ganglion neurons.Neurochemical research · 2010Article
- Development of rat stellate ganglion neurons containing membrane-bound muscarinic receptors and purinoreceptors.Neuroscience and behavioral physiology · 2010Article
- P2X3 receptor involvement in pain states.Molecular neurobiology · 2007Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of the P2X(3) nucleotide receptor in embryonic day 14-18, postnatal day 1-14 and adult mouse sensory ganglia was examined using immunohistochemistry. Nearly all sensory neurons in dorsal root ganglia, trigeminal ganglia and nodose ganglia in embryos at embryonic day 14 expressed P2X(3) receptors, but after birth there was a gradual decline to about 50% of neurons showing positive immunostaining for P2X(3). In embryos there were only small neurons, while from postnatal day 7 both large and small neurons were present. Isolectin B(4) (IB(4))-positive neurons in dorsal, trigeminal and nodose ganglia did not appear until birth, but the numbers increased to about 50% by postnatal day 14 when a high proportion of IB(4)-positive neurons were also positively labelled for the P2X(3) receptor. About 10% of neurons in dorsal, trigeminal and nodose ganglia were positive for calcitonin gene-related peptide in embryos, nearly all of which stained for P2X(3) receptors. This increased postnatally to about 35-40% in adults, although only a few colocalised with P2X(3) receptors. Neurofilament 200 was expressed in about 50% of neurons in trigeminal ganglia in the embryo, and this level persisted postnatally. All neurofilament 200-positive neurons stained for P2X(3) in embryonic dorsal root ganglia, trigeminal ganglia and nodose ganglia, but by adulthood this was significantly reduced. The neurons that were positive for calbindin in embryonic dorsal, trigeminal and nodose ganglia showed colocalisation with P2X(3) receptors, but few showed colocalisation postnatally.
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