ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Dendrodendritic electrical synapses between mammalian retinal ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 82 citations in OpenAlex.
- The Role of Connexin 36 Gap Junctions in Retinal Ganglion Cell Death After Corneal Alkali Burns.Investigative ophthalmology & visual science · 2025Article
- The structure, function, and distribution of gap junctions in the retina: Life cycle in health and disease.Journal of cell communication and signaling · 2025Review
- Extrinsic and Intrinsic Factors Determine Expression Levels of Gap Junction-Forming Connexins in the Mammalian Retina.Biomolecules · 2023Review
- Article
- Serotonin is a gap junction-permeable neuronal tracer in the mouse retina.Frontiers in ophthalmology · 2023Article
- The Role of GJD2(Cx36) in Refractive Error Development.Investigative ophthalmology & visual science · 2022Review
- Cell Types and Synapses Expressing the SNARE Complex Regulating Proteins Complexin 1 and Complexin 2 in Mammalian Retina.International journal of molecular sciences · 2021Article
- Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish.Communications biology · 2021Article
- Predicting synchronous firing of large neural populations from sequential recordings.PLoS computational biology · 2021Article
- Altered Expression of GJD2 Messenger RNA and the Coded Protein Connexin 36 in Negative Lens-induced Myopia of Guinea Pigs.Optometry and vision science : official publication of the American Academy of Optometry · 2020Article
- Electrical Coupling of Heterotypic Ganglion Cells in the Mammalian Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Gap junctions set the speed and nucleation rate of stage I retinal waves.PLoS computational biology · 2019Article
- Heterocellular Coupling Between Amacrine Cells and Ganglion Cells.Frontiers in neural circuits · 2018Article
- Strategic Positioning of Connexin36 Gap Junctions Across Human Retinal Ganglion Cell Dendritic Arbors.Frontiers in cellular neuroscience · 2018Article
- Connexin36 Expression in the Mammalian Retina: A Multiple-Species Comparison.Frontiers in cellular neuroscience · 2017Article
- Article
- Nonlinear dendritic integration of electrical and chemical synaptic inputs drives fine-scale correlations.Nature neuroscience · 2014Article
- Role of connexin channels in the retinal light response of a diurnal rodent.Frontiers in cellular neuroscience · 2014Article
- Dynamic tuning of electrical and chemical synaptic transmission in a network of motion coding retinal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Gap junctions are essential for generating the correlated spike activity of neighboring retinal ganglion cells.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrical synapses between alpha-type ganglion cells were detected using combined techniques of dual patch-clamp recordings, intracellular labeling, electron microscopy, and channel subunit connexin immunocytochemistry in the albino rat retina. After intracellular injection of Neurobiotin into alpha-cells of inner (ON-center) and outer (OFF-center) ramifying types, measurement of tracer coupling resulted in a preferentially homologous occurrence among cells of the same morphological type (n = 19 of 24). In high-voltage as well as conventional electron microscopic analysis, direct dendrodendritic gap junctions (average size, 0.86 mum long) were present in contact sites between tracer-coupled alpha-cells. In simultaneous dual whole-cell recordings from pairs of neighboring alpha-cells, these cells generated TTX-sensitive sustained spiking against extrinsic current injection, and bidirectional electrical synapses (maximum coupling coefficient, 0.32) with symmetrical junction conductance (average, 1.35 nS) were observed in pairs with cells of the same morphological type. Precise temporal synchronization of spike activity (average time delay, 2.7 msec) was detected when depolarizing currents were simultaneously injected into the pairs. To address whether physiologically identified electrical synapses constitute gap junctional connectivity between cell pairs, identified neuronal connexin36 immunoreactivity was undertaken in Lucifer yellow-labeled cell pairs after patch-clamp recordings. All alpha-cells expressed connexin36, and confocal laser-scanning imaging demonstrated that connexin36 is primarily located at dendritic crossings between electrically coupled cells (seven sites in a pair, on average). These results give conclusive evidence for electrical synapses via dendrodendritic gap junctions involving connexin36 in alpha retinal ganglion cells of the same physiological type.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.