ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Peptide Modulator of TRPV1 Channel Increases Long-Term Potentiation in the Hippocampus and Reduces Anxiety and Fear in Mice Under Acute Stress.Marine drugs · 2026Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- How Are Synapses Born? A Functional and Molecular View of the Role of the Wnt Signaling Pathway.International journal of molecular sciences · 2022Review
- Correlative Live-Cell and Super-Resolution Imaging to Link Presynaptic Molecular Organisation With Function.Frontiers in synaptic neuroscience · 2022Article
- Heat But Not Mechanical Hypersensitivity Depends on Voltage-Gated CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- N-type calcium channels control GABAergic transmission in brain areas related to fear and anxiety.OBM neurobiology · 2021Article
- Deep Learning-Assisted High-Throughput Analysis of Freeze-Fracture Replica Images Applied to Glutamate Receptors and Calcium Channels at Hippocampal Synapses.International journal of molecular sciences · 2020Article
- Age attenuates the transcriptional changes that occur with sleep in the medial prefrontal cortex.Aging cell · 2019Article
- Opposite Roles in Short-Term Plasticity for N-Type and P/Q-Type Voltage-Dependent Calcium Channels in GABAergic Neuronal Connections in the Rat Cerebral Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Co-transmission of acetylcholine and GABA regulates hippocampal states.Nature communications · 2018Article
- Short-Term Facilitation at a Detonator Synapse Requires the Distinct Contribution of Multiple Types of Voltage-Gated Calcium Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Review
- Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.Journal of neurophysiology · 2014Article
- Input-specific learning rules at excitatory synapses onto hippocampal parvalbumin-expressing interneurons.The Journal of physiology · 2013Article
- Ablation of Ca(V)2.1 voltage-gated Ca²⁺ channels in mouse forebrain generates multiple cognitive impairments.PloS one · 2013Article
- Presynaptic but not postsynaptic GABA signaling at unitary mossy fiber synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Independent regulation of basal neurotransmitter release efficacy by variable Ca²+ influx and bouton size at small central synapses.PLoS biology · 2012Article
- MicroRNA132 modulates short-term synaptic plasticity but not basal release probability in hippocampal neurons.PloS one · 2010Article
- Ca2+ current versus Ca2+ channel cooperativity of exocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin.Nature neuroscience · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Presynaptic calcium influx at most excitatory central synapses is carried by both Cav2.1 and Cav2.2 channels. The kinetics and modulation of Cav2.1 and Cav2.2 channels differ and may affect presynaptic calcium influx. We compared release dynamics at CA3/CA1 synapses in rat hippocampus after selective blockade of either channel subtype and subsequent quantal content restoration. Selective blockade of Cav2.1 channels enhanced paired-pulse facilitation, whereas blockade of Cav2.2 channels decreased it. This effect was observed at short (50 msec) but not longer (500 msec) intervals and was maintained during prolonged bursts of presynaptic activity. It did not reflect differences in the distance of the channels from the calcium sensor. The suppression of this effect by preincubation with the G(o/i)-protein inhibitor pertussis toxin suggests instead that high-frequency stimulation relieves inhibition of Cav2.2 by G(o/i), thereby increasing the number of available channels.
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Registered trials
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