ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
The subcellular organization of cortactin in hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 82 citations in OpenAlex.
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- Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons.Nature neuroscience · 2022Article
- Review
- Cortactin Contributes to Activity-Dependent Modulation of Spine Actin Dynamics and Spatial Memory Formation.Cells · 2021Article
- Article
- A Comparative Analysis of Erythropoietin and Carbamoylated Erythropoietin Proteome Profiles.Life (Basel, Switzerland) · 2021Article
- Abl2:Cortactin Interactions Regulate Dendritic Spine Stability via Control of a Stable Filamentous Actin Pool.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Distribution of cortactin in cerebellar Purkinje cell spines.Scientific reports · 2021Article
- Functional interactions of ion channels with the actin cytoskeleton: does coupling to dynamic actin regulate NMDA receptors?The Journal of physiology · 2021Review
- Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes.Nature communications · 2019Article
- α-Actinin Anchors PSD-95 at Postsynaptic Sites.Neuron · 2018Article
- Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes.Nature communications · 2018Article
- Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome.Science signaling · 2017Article
- Article
- Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development.Journal of neuroscience research · 2017Review
- Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling.Cellular and molecular life sciences : CMLS · 2016Review
- The Postsynaptic Density: There Is More than Meets the Eye.Frontiers in synaptic neuroscience · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spines may undergo rapid, activity-dependent changes in shape and size, reflecting reorganization of the actin cytoskeleton. This remodeling is implicated in development and also in the late phase of long-term potentiation. However, the cellular mechanisms that convert activity into morphological change remain poorly understood, and little is known about the anatomical distribution of the actin-regulating proteins that mediate this remodeling. Using immunocytochemistry, we demonstrate here that cortactin (a protein implicated in actin filament nucleation, branching, and stabilization) is concentrated in hippocampal spines, where it colocalizes with F-actin. Cortactin has a Shank-binding domain; recent studies report that synaptic activity may trigger actin remodeling via this interaction with Shank. However, our immunogold electron microscopic data show that cortactin concentrates within the spine core, 100-150 nm away from the postsynaptic density (PSD); only a small fraction of the cortactin in spines lies adjacent to the PSD. These data suggest that the adult dendritic spine contains two functional pools of cortactin: a large pool in the spine core that may help to mediates changes in spine shape and a small synaptic pool that may modify the PSD in response to synaptic activity.
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