ArticleNeoplasia (New York, N.Y.)
Differential regulation of a fibroblast growth factor-binding protein during skin carcinogenesis and wound healing.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Anti-Aging Effects ofGenes · 2020Article
- The Expression and Prognostic Value of FGF2, FGFR3, and FGFBP1 in Esophageal Squamous Cell Carcinoma.Analytical cellular pathology (Amsterdam) · 2020Article
- Knockdown of lncRNA PVT1 Inhibits Glioma Progression by Regulating miR-424 Expression.Oncology research · 2019Article
- Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism.Scientific reports · 2018Article
- The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation.The Journal of investigative dermatology · 2018Article
- Ghrelin Ameliorates Traumatic Brain Injury by Down-Regulating bFGF and FGF-BP.Frontiers in neuroscience · 2018Article
- A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia.The Journal of clinical investigation · 2014Article
- 1α,25(OH)₂D₃ inhibits FGF-2 release from oral squamous cell carcinoma cells through down-regulation of HBp17/FGFBP-1.In vitro cellular & developmental biology. Animal · 2014Article
- Expression of a Secreted Fibroblast Growth Factor Binding Protein-1 (FGFBP1) in Angioproliferative Kaposi Sarcoma.Journal of AIDS & clinical research · 2014Article
- Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma.Molecular cancer · 2011Article
- Impact of fibroblast growth factor-binding protein-1 expression on angiogenesis and wound healing.The American journal of pathology · 2011Article
- A novel enhancer of the wound healing process: the fibroblast growth factor-binding protein.The American journal of pathology · 2011Article
- Origins of injection-site sarcomas in cats: the possible role of chronic inflammation-a review.ISRN veterinary science · 2011Article
- Article
- Effect of FGF-binding protein 3 on vascular permeability.The Journal of biological chemistry · 2008Article
- Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate.Cancer research · 2008Article
- A review of the past, present, and future directions of neoplasia.Neoplasia (New York, N.Y.) · 2005Review
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The initiation of premalignant lesions is associated with subtle cellular and gene expression changes. Here we describe a severe combined immunodeficiency mouse xenograft model with human adult skin and compare chemical carcinogenesis and wound healing. We focus on a secreted binding protein for fibroblast growth factors (FGF-BP) that enhances the activity of locally stored FGFs and is expressed at high levels in human epithelial cancers. Carcinogen treatment of murine skin induced papilloma within 6 weeks, whereas the human skin grafts displayed no obvious macroscopic alterations. Microscopic studies of the human skin, however, showed p53-positive keratinocytes in the epidermis, increased angiogenesis in the dermis of the treated skin, enhanced proliferation of keratinocytes in the basal layer, and an increase of FGF-BP protein and mRNA expression. In contrast, after surgical wounding of human skin grafts or of mouse skin, FGF-BP expression was upregulated within a few hours and returned to control levels after 2 days with wound closure. Enhanced motility of cultured keratinocytes and dermal fibroblasts by FGF-BP supports a role in wound healing. We conclude that adult human skin xenografts can be used to identify early molecular events during malignant transformation as well as transient changes during wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.