ArticleNeoplasia (New York, N.Y.)
Transcriptional repression of catalase in mouse skin tumor progression.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Enhanced Protective Potential of a Pea Protein-Fortified Fermented Almond Beverage Against Paraquat-Induced Oxidative Stress.Molecular nutrition & food research · 2026Article
- The SGK3-Catalase antioxidant signaling axis drives cervical cancer growth and therapy resistance.Redox biology · 2023Article
- Article
- Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death.Journal of oncology · 2022Review
- Catalase Overexpression Drives an Aggressive Phenotype in Glioblastoma.Antioxidants (Basel, Switzerland) · 2021Article
- Metabolomic Identification of Anticancer Metabolites of Australian Propolis and Proteomic Elucidation of Its Synergistic Mechanisms with Doxorubicin in the MCF7 Cells.International journal of molecular sciences · 2021Article
- The Quest to Quantify Selective and Synergistic Effects of Plasma for Cancer Treatment: Insights from Mathematical Modeling.International journal of molecular sciences · 2021Article
- Reactive oxygen species in cancer: a paradox between pro- and anti-tumour activities.Cancer chemotherapy and pharmacology · 2020Review
- Catalase immunoexpression in colorectal lesions.Przeglad gastroenterologiczny · 2020Article
- Heterogeneous Fenton Reaction Enabled Selective Colon Cancerous Cell Treatment.Scientific reports · 2018Article
- Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin.Radiation research · 2017Article
- Downregulation of catalase by CuO nanoparticlesToxicology research · 2017Article
- Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1β-induced IL-6 expression in human OA chondrocytes.Connective tissue research · 2017Article
- Prophylaxis of Diallyl Disulfide on Skin Carcinogenic Model via p21-dependent Nrf2 stabilization.Scientific reports · 2016Article
- Anticancer therapeutic potential of Mn porphyrin/ascorbate system.Free radical biology & medicine · 2015Article
- A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.Free radical biology & medicine · 2015Article
- SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.Antioxidants & redox signaling · 2014Review
- Preventative topical diclofenac treatment differentially decreases tumor burden in male and female Skh-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma.Carcinogenesis · 2013Article
- Manganese superoxide dismutase, MnSOD and its mimics.Biochimica et biophysica acta · 2012Review
- UV light B-mediated inhibition of skin catalase activity promotes Gr-1+ CD11b+ myeloid cell expansion.The Journal of investigative dermatology · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies in our laboratory have shown that the elevation of reactive oxygen species levels and the repression of the antioxidant enzyme, catalase, played a critical role in the in vitro progression of benign papilloma cells to malignant carcinoma cells. Catalase message, protein levels, and activity levels were found to be downregulated in the malignantly progressed cells. The goal of this study is to further characterize the repression of catalase in malignant progression of mouse skin tumors. To validate the in vitro observations, we examined catalase expression in tumor samples generated by the multistep chemical carcinogenesis protocol. Higher levels of catalase mRNA and protein were observed in benign papillomas versus malignant carcinomas. Nuclear run-on analysis showed that catalase repression in the cultured malignant cells was transcription-dependent. Results from luciferase reporter assays indicated that malignant cells have lower catalase promoter activities than benign papilloma cells, in part through the Wilm's tumor suppressor 1 (WT1) binding site within the proximal promoter region. The WT1 protein levels were found to be inversely correlated with the observed catalase promoter activities, with higher levels observed in the malignant cells versus the benign cells. These results led us to conclude that WT1 is acting as a transcription repressor in catalase gene regulation during tumor progression.
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