ArticleAmerican journal of human genetics2005
Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- The Swedish version of the Diagnostic Interview for Social and Communication Disorders (DISCO-10). Psychometric properties.Journal of autism and developmental disorders · 2009Guideline
- A preliminary randomized, controlled trial of executive function training for children with autism spectrum disorder.Autism : the international journal of research and practice · 2022Trial
- Mind the Gap: Executive Function Is Associated with the Discrepancy Between Cognitive and Adaptive Functioning in Autistic Children Without Cognitive Delay.Journal of autism and developmental disorders · 2025Article
- Resting-state EEG Microstate Features Can Quantitatively Predict Autistic Traits in Typically Developing Individuals.Brain topography · 2024Article
- Social motivation in infancy is associated with familial recurrence of ASD.Development and psychopathology · 2024Article
- Spanning three decades: global research wave and future prospects of broader autism phenotype-a visual researches by CiteSpace and VOS viewer.Frontiers in psychology · 2024Review
- Fundamental behavioral and neurophysiologic relationships between sensory processing, intolerance of uncertainty, and autistic traits in children: A hybrid approach.Biological psychology · 2023Article
- Childhood Academic Performance: A Potential Marker of Genetic Liability to Autism.Journal of autism and developmental disorders · 2023Article
- Social attention in anorexia nervosa and autism spectrum disorder: Role of social motivation.Autism : the international journal of research and practice · 2022Article
- Brief Report: Test-Retest Reliability of Cognitive, Affective, and Spontaneous Theory of Mind Tasks Among School-Aged Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022Article
- Prevention in Autism Spectrum Disorder: A Lifelong Focused Approach.Brain sciences · 2021Review
- The broader autism phenotype constellations-disability matrix paradigm: Theoretical model for autism and the broader autism phenotype.Medical hypotheses · 2021Article
- Relationship Between Social Motivation in Children With Autism Spectrum Disorder and Their Parents.Frontiers in neuroscience · 2021Article
- Genetic influences of autism candidate genes on circuit wiring and olfactory decoding.Cell and tissue research · 2021Review
- Brain Opioid Activity and Oxidative Injury: Different Molecular Scenarios Connecting Celiac Disease and Autistic Spectrum Disorder.Brain sciences · 2020Review
- Variation in restricted and repetitive behaviors and interests relates to inhibitory control and shifting in children with autism spectrum disorder.Autism : the international journal of research and practice · 2019Article
- Measuring Individual Differences in Cognitive, Affective, and Spontaneous Theory of Mind Among School-Aged Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2018Article
- Increase of cytosolic phospholipase A2 as hydrolytic enzyme of phospholipids and autism cognitive, social and sensory dysfunction severity.Lipids in health and disease · 2017Article
- Infant social attention: an endophenotype of ASD-related traits?Journal of child psychology and psychiatry, and allied disciplines · 2017Article
- Using standardized diagnostic instruments to classify children with autism in the study to explore early development.Journal of autism and developmental disorders · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Autism is a severe developmental disorder of unknown etiology but with evidence for genetic influences. Here, we provide evidence for a genetic basis of several quantitative traits that are related to autism. These traits, from the Broader Phenotype Autism Symptom Scale (BPASS), were measured in nuclear families, each ascertained through two probands affected by autism spectrum disorder. The BPASS traits capture the continuum of severity of impairments and may be more informative for genetic studies than are the discrete diagnoses of autism that have been used by others. Using a sample of 201 nuclear families consisting of a total of 694 individuals, we implemented multivariate polygenic models with ascertainment adjustment to estimate heritabilities and genetic and environmental correlations between these traits. Our ascertainment adjustment uses conditioning on the phenotypes of probands, requires no modeling of the ascertainment process, and is applicable to multiplex ascertainment and multivariate traits. This appears to be the first such implementation for multivariate quantitative traits. The marked difference between heritability estimates of the trait for language onset with and without an ascertainment adjustment (0.08 and 0.22, respectively) shows that conclusions are sensitive to whether or not an ascertainment adjustment is used. Among the five BPASS traits that were analyzed, the traits for social motivation and range of interest/flexibility show the highest heritability (0.19 and 0.16, respectively) and also have the highest genetic correlation (0.92). This finding suggests a shared genetic basis of these two traits and that they may be most promising for future gene mapping and for extending pedigrees by phenotyping additional relatives.
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Registered trials
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