ArticleAnnals of the rheumatic diseases2004
Bone mineral density in patients with rheumatoid arthritis: relation between disease severity and low bone mineral density.
Article in Annals of the rheumatic diseases, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.
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Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 204 citations in OpenAlex.
- Combination effects of herbal and western medicines on osteoporosis in rheumatoid arthritis: systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Bone mineral density of postmenopausal women with rheumatoid arthritis depends on disease duration regardless of treatment.Journal of bone and mineral metabolism · 2017Trial
- Evaluation of calcium and phosphorus elements in the developing human fetal long bone at different trimesters of pregnancy.Anatomy & cell biology · 2026Article
- An interpretable machine learning model integrating ultrasound and clinical variables for predicting osteoporosis in patients with rheumatoid arthritis.Clinical rheumatology · 2026Article
- Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis.Arthritis care & research · 2026Article
- High disease activity is associated with incident osteoporotic fractures among veterans with rheumatoid arthritis.Joint bone spine · 2026Article
- Bone health in young adults with inflammatory arthritis: assessment of associated factors of low bone mineral density.Archives of osteoporosis · 2026Article
- Inflammatory cytokines mediate the common genetic and immunological background between rheumatoid arthritis and osteoporosis.Clinical rheumatology · 2026Article
- Higher revision rates in primary total hip arthroplasty among patients with rheumatoid arthritis compared with osteoarthritis.Bone & joint open · 2025Article
- Cyclin-dependent kinase inhibitor-1 deficiency enhances bone destruction in a mouse model of arthritis.Bone reports · 2025Article
- Advances in biomonitoring technologies for women's health.Nature communications · 2025Review
- Clinical insights into the role of smoking, diabetes, and rheumatoid arthritis in osteoporotic fractures.Archives of osteoporosis · 2025Review
- Association between rheumatoid arthritis and kidney stones: A cross-sectional study of NHANES 2007-2020.Arthritis research & therapy · 2025Article
- Article
- Bacterial and host interactions inFrontiers in microbiology · 2025Review
- Incidence and outcomes of intraoperative periprosthetic acetabular fractures during cementless total hip arthroplasty: a prospective three-dimensional computer tomography-based study.International orthopaedics · 2024Article
- Skeletal muscle index together with body mass index is associated with secondary osteoporosis in patients with rheumatoid arthritis.European journal of medical research · 2024Article
- Pain score as a predictor of subsequent fragility fracture in postmenopausal patients with rheumatoid arthritis: A retrospective case-control study.Osteoporosis and sarcopenia · 2023Article
- Effect of Hypertension on Bone Mineral Density of Patients with Rheumatoid Arthritis.Mediterranean journal of rheumatology · 2023Article
- The relative contribution of co-morbidities to health-related quality of life of people with idiopathic pulmonary fibrosis using the Assessment of Quality of Life-8-Dimension multi-attribute utility instrument.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine variables associated with bone mineral density (BMD) in patients with rheumatoid arthritis (RA).
methodsWe investigated 373 patients with low to moderately active RA. Patients with low disease activity were recruited from a cohort of patients in clinical remission. Patients with moderately active disease were included in a trial comparing the effects of long term high intensity exercise programme and conventional physical therapy. Demographic and clinical data were collected. Bone mineral density (BMD) was measured by means of dual x ray absorptiometry (DXA). Associations between demographic and clinical measurements on the one hand and BMD on the other were investigated in regression analyses.
resultsThe patient group consisted of middle aged, mainly female, patients. The median (interquartile range) disease duration was 7 (4 to 13) years, the mean disease activity score (standard deviation) was 3.2 (1.4). Of the group, 66% was rheumatoid factor positive, and 83% (n = 304) had never used corticosteroids. The median Larsen score of hands and feet was 27 (5 to 61). Greater age and low body mass index were related to low BMD at the hip and spine. High Larsen score for hands and feet was significantly associated with low BMD at the hip. The use of corticosteroids was not independently associated with BMD. The results of the multiple regression analyses also applied to the subgroup of corticosteroid naive patients.
conclusionBMD data of patients with low to moderately active RA demonstrated an association between high radiological RA damage and low BMD at the hip, which suggests an association between the severity of RA and the risk of generalised bone loss, which also occurred in corticosteroid naive patients.
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