ArticleProceedings of the National Academy of Sciences of the United States of America2004
Impaired adrenal stress response in Toll-like receptor 2-deficient mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 91 citations in OpenAlex.
- Deficiency of Toll-like receptor 2 is a driver of sex-related compositional and structural rearrangements of membrane lipids.Communications chemistry · 2025Article
- Reply to Karadag: does steroid increase LPS-induced sickness behaviors?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Co-culture of monocytes and zona fasciculata adrenal cells: An in vitro model to study the immune-adrenal cross-talk.Molecular and cellular endocrinology · 2021Article
- Stress Response Simulated by Continuous Injection of ACTH Attenuates Lipopolysaccharide-Induced Inflammation in Porcine Adrenal Gland.Frontiers in veterinary science · 2020Article
- Interactions Between Gut Microbiota and Acute Restraint Stress in Peripheral Structures of the Hypothalamic-Pituitary-Adrenal Axis and the Intestine of Male Mice.Frontiers in immunology · 2019Article
- Critical illness-related corticosteroid insufficiency (CIRCI): a narrative review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM).Intensive care medicine · 2017Review
- Memory Training Program Decreases the Circulating Level of Cortisol and Pro-inflammatory Cytokines in Healthy Older Adults.Frontiers in molecular neuroscience · 2017Article
- Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis.BMC gastroenterology · 2016Article
- The Role of ACTH and Corticosteroids for Sepsis and Septic Shock: An Update.Frontiers in endocrinology · 2016Review
- Pituitary CRH-binding protein and stress in female mice.Physiology & behavior · 2015Article
- One hormone, two actions: anti- and pro-inflammatory effects of glucocorticoids.Neuroimmunomodulation · 2015Review
- Anesthetic cardioprotection: the role of adenosine.Current pharmaceutical design · 2014Review
- Key role of CRF in the skin stress response system.Endocrine reviews · 2013Review
- Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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- Minireview: Glucocorticoids in autoimmunity: unexpected targets and mechanisms.Molecular endocrinology (Baltimore, Md.) · 2011Review
- Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients.Critical care (London, England) · 2011Article
- Role for Toll-like receptor 2 in the immune response to Streptococcus pneumoniae infection in mouse otitis media.Infection and immunity · 2009Article
- Mortality in human sepsis is associated with downregulation of Toll-like receptor 2 and CD14 expression on blood monocytes.Diagnostic pathology · 2009Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Septicemia is one of the major health concerns worldwide, and rapid activation of adrenal steroid release is a key event in the organism's first line of defense during this form of severe illness. The family of Toll-like receptors (TLRs) is critical in the early immune response upon bacterial infection, and TLR polymorphisms are frequent in humans. Here, we demonstrate that TLR-2 deficiency in mice is associated with reduced plasma corticosterone levels and marked cellular alterations in adrenocortical tissue. TLR-2-deficient mice have an impaired adrenal corticosterone release after inflammatory stress induced by bacterial cell wall compounds. This defect appears to be mediated by a decrease in systemic and intraadrenal cytokine expression, including IL-1, tumor necrosis factor alpha, and IL-6. Our data demonstrate a link between the innate immune system and the endocrine stress response. The critical role of TLR-2 in adrenal glucocorticoid regulation needs to be considered in patients with inflammatory disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.