ArticleCancer science2004
Novel models for human scirrhous gastric carcinoma in vivo.
Article in Cancer science, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- How doesWorld journal of gastroenterology · 2019Review
- Identification of candidates for driver oncogenes in scirrhous-type gastric cancer cell lines.Cancer science · 2019Article
- Differential gene expression in growth factors, epithelial mesenchymal transition and chemotaxis in the diffuse type compared with the intestinal type of gastric cancer.Oncology letters · 2019Article
- The significance of scirrhous gastric cancer cell lines: the molecular characterization using cell lines and mouse models.Human cell · 2018Review
- Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Review
- Tks5 activation in mesothelial cells creates invasion front of peritoneal carcinomatosis.Oncogene · 2015Article
- Characterization of gastric cancer models from different cell lines orthotopically constructed using improved implantation techniques.World journal of gastroenterology · 2012Article
- Biological significance of localized Type IV scirrhous gastric cancer.Oncology letters · 2012Article
- An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells.British journal of cancer · 2011Article
- Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.Oncogene · 2011Article
- Serial observations on an orthotopic gastric cancer model constructed using improved implantation technique.World journal of gastroenterology · 2011Article
- Phosphorylated smad2 in advanced stage gastric carcinoma.BMC cancer · 2010Article
- The epidermal growth factor receptor inhibitor gefitinib prevents the progression of pancreatic lesions to carcinoma in a conditional LSL-KrasG12D/+ transgenic mouse model.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Establishment and characterization of a new hypoxia-resistant cancer cell line, OCUM-12/Hypo, derived from a scirrhous gastric carcinoma.British journal of cancer · 2010Article
- Cancer-stromal interactions in scirrhous gastric carcinoma.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2010Article
- Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer.Cancer science · 2009Article
- Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model.British journal of cancer · 2009Article
- Recent results of therapy for scirrhous gastric cancer.Surgery today · 2009Review
- Gastric Cancer: Identification of microRNAs Inhibiting Druggable Targets and Mediating Efficacy in PreclinicalCancer genomics & proteomicsReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human scirrhous gastric carcinoma, a diffusely infiltrating type of poorly differentiated gastric carcinoma also known as linitis plastica type carcinoma, is characterized by cancer cell infiltration and proliferation accompanied with extensive stromal fibrosis. We established two new gastric cancer cell lines, designated OUCM-8 and OCUM-11, which developed the characteristic biology of scirrhous gastric carcinoma upon orthotopic implantation in mice. Involvement of lymph nodes and liver metastasis was also found in both orthotopic models. Histologically, these orthotopic models showed proliferation with extensive fibrosis, resembling human scirrhous gastric cancer. Both cell lines were derived from ascites of patients with scirrhous gastric cancer. The growth of OCUM-8 and OCUM-11 cells following the addition of KGF, FGF, and EGF was increased significantly relative to untreated cells. An increase in the number of attached and spreading cells occurred following the addition of TGF-beta 1 in both cell lines. OCUM-11 cells showed microsatellite instability. Although subcutaneous scirrhous gastric cancer cells show medullary growth, most in vivo studies of scirrhous gastric cancer have used xenografted tumors implanted subcutaneously. Only in a few cases was it confirmed that these scirrhous gastric cancer cell lines retained the original histologic characteristics. Our orthotopic models should contribute to the elucidation of disease progression in situ and to the development of therapy for scirrhous gastric cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.