ArticleThe Journal of clinical investigation2004
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 97 citations in OpenAlex.
- Article
- The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury.Neurobiology of disease · 2021Article
- Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis.Journal of thrombosis and haemostasis : JTH · 2020Article
- Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function.Frontiers in immunology · 2019Article
- Targeting PAR1: Now What?Trends in pharmacological sciences · 2017Review
- Genetic targeting of protease activated receptor 2 reduces inflammatory astrogliosis and improves recovery of function after spinal cord injury.Neurobiology of disease · 2015Article
- Enterococcus faecalis Gelatinase Mediates Intestinal Permeability via Protease-Activated Receptor 2.Infection and immunity · 2015Article
- Endothelial dysfunction in cirrhosis: Role of inflammation and oxidative stress.World journal of hepatology · 2015Review
- Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome.Annals of gastroenterology · 2014Review
- The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation.Genes · 2013Article
- Article
- Inhibition of protease-activated receptor 1 ameliorates intestinal radiation mucositis in a preclinical rat model.International journal of radiation oncology, biology, physics · 2013Article
- Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications.World journal of gastroenterology · 2013Review
- Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine.The American journal of pathology · 2012Article
- Article
- Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells.The Journal of biological chemistry · 2011Article
- Haemostatic system in inflammatory bowel diseases: new players in gut inflammation.World journal of gastroenterology · 2011Review
- The protein C pathway and pathologic processes.Journal of thrombosis and haemostasis : JTH · 2009Review
- Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1.Thrombosis and haemostasis · 2009Article
- Anti-Inflammatory mechanisms of enteric Heligmosomoides polygyrus infection against trinitrobenzene sulfonic acid-induced colitis in a murine model.Infection and immunity · 2008Article
Corrections and comments
- Retraction · 2006-07-03Criminal Proceedings · Euphemisms for Duplication · Investigation by Company/Institution · Investigation by Third Party · Manipulation of Images ·
- Retracted
Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteinase-activated receptor-1 (PAR1), a G protein-coupled receptor activated by thrombin, is highly expressed in different cell types of the gastrointestinal tract. The activity of thrombin and of other proteinases is significantly increased in the colon of inflammatory bowel disease (IBD) patients. Since PAR1 activation in tissues other than the gut provoked inflammation, we hypothesized that PAR1 activation in the colon is involved in the pathogenesis of IBD. Here, we demonstrate that PAR1 is overexpressed in the colon of IBD patients. In mice, intracolonic administration of PAR1 agonists led to an inflammatory reaction characterized by edema and granulocyte infiltration. This PAR1 activation-induced inflammation was dependent on B and T lymphocytes. Moreover, PAR1 activation exacerbated and prolonged inflammation in a mouse model of IBD induced by the intracolonic administration of trinitrobenzene sulfonic acid (TNBS), while PAR1 antagonism significantly decreased the mortality and severity of colonic inflammation induced by TNBS and dextran sodium sulfate. In these 2 models, colitis development was strongly attenuated by PAR1 deficiency. Taken together, these results imply an important role for PAR1 in the pathogenesis of experimental colitis, supporting the notion that PAR1 inhibition may be beneficial in the context of IBD and possibly in other chronic intestinal inflammatory disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.