ArticleGenetics2005
Patterns of selection on synonymous and nonsynonymous variants in Drosophila miranda.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Article
- Recombination modulates how selection affects linked sites in Drosophila.PLoS biology · 2012Article
- The effect of variation in the effective population size on the rate of adaptive molecular evolution in eukaryotes.Genome biology and evolution · 2012Article
- Weighing the evidence for adaptation at the molecular level.Trends in genetics : TIG · 2011Article
- The effects of demography and linkage on the estimation of selection and mutation parameters.Genetics · 2010Article
- Estimating the parameters of selection on nonsynonymous mutations in Drosophila pseudoobscura and D. miranda.Genetics · 2010Article
- Studying patterns of recent evolution at synonymous sites and intronic sites in Drosophila melanogaster.Journal of molecular evolution · 2010Article
- Patterns of DNA-sequence divergence between Drosophila miranda and D. pseudoobscura.Journal of molecular evolution · 2009Article
- Strong evidence for lineage and sequence specificity of substitution rates and patterns in Drosophila.Molecular biology and evolution · 2009Article
- Pervasive natural selection in the Drosophila genome?PLoS genetics · 2009Article
- Similar rates of protein adaptation in Drosophila miranda and D. melanogaster, two species with different current effective population sizes.BMC evolutionary biology · 2008Article
- Article
- Non-neutral processes drive the nucleotide composition of non-coding sequences in Drosophila.Biology letters · 2008Article
- Functional diversification of paralogous transcription factors via divergence in DNA binding site motif and in expression.PloS one · 2008Article
- A tutorial of the poisson random field model in population genetics.Advances in bioinformatics · 2008Article
- Neo-sex chromosomes in the black muntjac recapitulate incipient evolution of mammalian sex chromosomes.Genome biology · 2008Article
- Article
- Patterns of molecular variation and evolution in Drosophila americana and its relatives.Genetics · 2007Article
- Reduced selection for codon usage bias in Drosophila miranda.Journal of molecular evolution · 2007Article
- Article
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Authors and funding
5 authors.
Funding
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Abstract
We have investigated patterns of within-species polymorphism and between-species divergence for synonymous and nonsynonymous variants at a set of autosomal and X-linked loci of Drosophila miranda. D. pseudoobscura and D. affinis were used for the between-species comparisons. The results suggest the action of purifying selection on nonsynonymous, polymorphic variants. Among synonymous polymorphisms, there is a significant excess of synonymous mutations from preferred to unpreferred codons and of GC to AT mutations. There was no excess of GC to AT mutations among polymorphisms at noncoding sites. This suggests that selection is acting to maintain the use of preferred codons. Indirect evidence suggests that biased gene conversion in favor of GC base pairs may also be operating. The joint intensity of selection and biased gene conversion, in terms of the product of effective population size and the sum of the selection and conversion coefficients, was estimated to be approximately 0.65.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.