ArticleThe Journal of cell biology2004
Pex7p translocates in and out of peroxisomes in Saccharomyces cerevisiae.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed, 119 citations in OpenAlex.
- Article
- Import mechanism of peroxisomal proteins with an N-terminal signal sequence.Nature cell biology · 2025Article
- Illuminating the Cryptococcus neoformans species complex: unveiling intracellular structures with fluorescent-protein-based markers.Genetics · 2024Article
- Towards solving the mystery of peroxisomal matrix protein import.Trends in cell biology · 2024Review
- Peroxin MoPex22 Regulates the Import of Peroxisomal Matrix Proteins and Appressorium-Mediated Plant Infection inJournal of fungi (Basel, Switzerland) · 2024Article
- PEX5 translocation into and out of peroxisomes drives matrix protein import.Molecular cell · 2022Article
- MrPEX33 is involved in infection-related morphogenesis and pathogenicity of Metarhizium robertsii.Applied microbiology and biotechnology · 2021Article
- The autophagic degradation of cytosolic pools of peroxisomal proteins by a new selective pathway.Autophagy · 2020Article
- A defect in the peroxisomal biogenesis in germ cells induces a spermatogenic arrest at the round spermatid stage in mice.Scientific reports · 2019Article
- Peroxisome biogenesis, membrane contact sites, and quality control.EMBO reports · 2019Review
- Identification and Localization of Peroxisomal Biogenesis Proteins Indicates the Presence of Peroxisomes in the Cryptophyte Guillardia theta and Other "Chromalveolates".Genome biology and evolution · 2018Article
- E3 ubiquitin ligase SP1 regulates peroxisome biogenesis in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Covalent Label Transfer between Peroxisomal Importomer Components Reveals Export-driven Import Interactions.The Journal of biological chemistry · 2016Article
- Peroxisome biogenesis and human peroxisome-deficiency disorders.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2016Review
- Revisiting the intraperoxisomal pathway of mammalian PEX7.Scientific reports · 2015Article
- Multiple pathways for protein transport to peroxisomes.Journal of molecular biology · 2015Review
- The unique degradation pathway of the PTS2 receptor, Pex7, is dependent on the PTS receptor/coreceptor, Pex5 and Pex20.Molecular biology of the cell · 2014Article
- A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway.Molecular and cellular biology · 2014Article
- Peroxisome biogenesis in mammalian cells.Frontiers in physiology · 2014Review
- A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pex7p is the soluble receptor responsible for importing into peroxisomes newly synthesized proteins bearing a type 2 peroxisomal targeting sequence. We observe that appending GFP to Pex7p's COOH terminus shifts Pex7p's intracellular distribution from predominantly cytosolic to predominantly peroxisomal in Saccharomyces cerevisiae. Cleavage of the link between Pex7p and GFP within peroxisomes liberates GFP, which remains inside the organelle, and Pex7p, which exits to the cytosol. The reexported Pex7p is functional, resulting in import of thiolase into peroxisomes and improved growth of the yeast on oleic acid. These results support the "extended shuttle" model of peroxisome import receptor function and open the way to future studies of receptor export.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.