ArticleClinical and experimental immunology2004
Cellular and humoral immune responses to mycobacterial heat shock protein-65 and its human homologue in Takayasu's arteritis.
Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Association between Takayasu arteritis and latent or active Mycobacterium tuberculosis infection: a systematic review.Clinical rheumatology · 2020Pooled it
- Article
- Insight Into the Role of NLRP3 Inflammasomes in Takayasu's Arteritis: Mechanisms and Targeted Pharmacotherapies.Reviews in cardiovascular medicine · 2025Review
- Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritis.Arthritis research & therapy · 2023Article
- High prevalence of latent tuberculosis using the QuantiFERON-TB Gold Plus test in Takayasu arteritis.Archives of rheumatology · 2022Article
- Large-vessel vasculitis.Nature reviews. Disease primers · 2022Review
- Advances in Takayasu arteritis: An Asia Pacific perspective.Frontiers in medicine · 2022Review
- Is Takayasu arteritis the result of a Mycobacterium tuberculosis infection? The use of TNF inhibitors may be the proof-of-concept to demonstrate that this association is epiphenomenal.Clinical rheumatology · 2020Review
- Case Report: Co-existence of sarcoidosis and Takayasu arteritis.Wellcome open research · 2020Article
- Tuberculosis Infection in Chinese Patients with Giant Cell Arteritis.Scientific reports · 2019Article
- Tuberculosis in Takayasu arteritis: a retrospective study in 1105 Chinese patients.Journal of geriatric cardiology : JGC · 2019Article
- Genetic polymorphism of HLA-DRB1 alleles in Mexican mestizo patients with abdominal aortic aneurysms.BMC medical genetics · 2019Article
- Takayasu arteritis - epidemiology, pathogenesis, diagnosis and treatment.Journal of applied biomedicine · 2019Review
- New Insights on the Pathogenesis of Takayasu Arteritis: Revisiting the Microbial Theory.Pathogens (Basel, Switzerland) · 2018Review
- High Secretion of Interleukin-6 and Increased MINCLE Receptor Expression Upon Exposure to Mycobacterial Cord Factor Analog Trehalose-6, 6-Dibehenate (TDB) in Patients with Takayasu Arteritis.The open rheumatology journal · 2018Article
- Takayasu Arteritis.Frontiers in pediatrics · 2018Review
- Absence of mycobacterial DNA in peripheral blood and artery specimens in patients with Takayasu arteritis.Clinical rheumatology · 2017Article
- Comparison of clinical characteristics in patients with Takayasu arteritis with and without concomitant tuberculosis.Heart and vessels · 2016Article
- Pathophysiological Relationship between Infections and Systemic Vasculitis.Autoimmune diseases · 2015Review
- Association of ferritin antibodies with Takayasu arteritis.Clinical rheumatology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of heat shock protein (HSP)-65 as well as infiltration of T-cells in arterial lesions and raised levels of circulating antibodies against mycobacterial HSP65 (mHSP65) led us to the concept that mHSP65 or its human homologue (hHSP60) might be involved in the etiopathogenesis of Takayasu's arteritis (TA). Therefore, we investigated mHSP65 and hHSP60 reactive peripheral blood T-cell subsets by BrdU incorporation assay and flow cytometry as well as investigating the different isotypes of anti-mHSP65 and hHSP60 antibodies by ELISA. Eighty-four percent (22/26) of the TA patients were observed to show T-cell proliferation to mHSP65 and hHSP60 whereas only 16% (3/18) healthy controls showed such proliferation (P <0.001). Both HSPs induced proliferation of exclusively CD4+ T-cells and not CD8+ T-cells. We also observed a significantly higher prevalence of only the IgG isotype reactive to mHSP65 and hHSP60 in TA as compared to HC (mHSP65: 92% TA versus 11% HC, P <0.0001 and hHSP60: 84% versus 22%, P <0.001). Our data show a significant correlation between mHSP65 and hHSP60 reactive T-cells (CD3+: r=0.901; CD4+: r=0.968) as well as anti-mHSP65 and anti-hHSP60 IgG antibodies (r=0.814) suggesting an infection induced autoimmunity in TA, possibly induced by molecular mimicry between mHSP65 and hHSP60 or other tissue specific antigens.
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Registered trials
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