ArticleClinical and experimental immunology2004
Co-infection of malaria and gamma-herpesvirus: exacerbated lung inflammation or cross-protection depends on the stage of viral infection.
Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Nontypeable Haemophilus influenzae challenge during gammaherpesvirus infection enhances viral reactivation and latency.Virology · 2024Article
- Association between Epstein-Barr virus reactivation and severe malaria in pregnant women living in a malaria-endemic region of Cameroon.PLOS global public health · 2024Article
- Prospects on Repurposing a Live Attenuated Vaccine for the Control of Unrelated Infections.Frontiers in immunology · 2022Review
- A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced immunopathologies.Mucosal immunology · 2020Article
- TFrontiers in immunology · 2019Review
- Herpesviruses: Harmonious Pathogens but Relevant Cofactors in Other Diseases?Frontiers in cellular and infection microbiology · 2018Review
- Beta and Gamma Human Herpesviruses: Agonistic and Antagonistic Interactions with the Host Immune System.Frontiers in microbiology · 2017Review
- Does EBV alter the pathogenesis of malaria?Parasite immunology · 2015Review
- Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity.PLoS pathogens · 2015Article
- Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection.eLife · 2015Article
- Review
- Malarial pathocoenosis: beneficial and deleterious interactions between malaria and other human diseases.Frontiers in physiology · 2014Review
- Latent gammaherpesvirus 68 infection induces distinct transcriptional changes in different organs.Journal of virology · 2014Article
- MHV68 latency modulates the host immune response to influenza A virus.Inflammation · 2013Article
- Chronic bystander infections and immunity to unrelated antigens.Cell host & microbe · 2012Review
- Immune modulation during latent herpesvirus infection.Immunological reviews · 2012Review
- Herpesvirus latency and symbiotic protection from bacterial infection.Viral immunology · 2009Article
- Pneumocystis infection enhances antibody-mediated resistance to a subsequent influenza infection.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
In order to study the interaction between a gamma-herpesvirus and malaria we established a co-infection model that involves infection of mice with murine gamma-herpesvirus (MHV-68) and Plasmodium yoelii non-lethal strain (PYNL). To investigate the interaction between acute malaria and the lytic stage of MHV-68, the timing of infections was chosen such that the peak virus and parasite burdens would be present at the same time. Under this condition, we observed significant mortality in co-infected mice and aggressive lung inflammation with a marked influx of neutrophils and megakaryocytes. If mice were latently infected with MHV-68 and then co-infected with malaria we noticed significantly less viral load and parasitaemia. Using MHC/peptide tetramer staining we found that acute malaria reduces the anti-MHV-68 CD8+ T cell response in the animals that develop severe disease. Our study provides important fundamental information, which will be of use when devising strategies to combat infections with more than one agent, a situation that often occurs naturally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.