ArticleMolecular and cellular biochemistry2004
Expression of endothelial nitric oxide synthase in the vascular wall during arteriogenesis.
Article in Molecular and cellular biochemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Integrated Strategies for Targeting Arteriogenesis and Angiogenesis After Stroke.Translational stroke research · 2025Review
- Vessel Enlargement in Development and Pathophysiology.Frontiers in physiology · 2021Review
- Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling.Comprehensive Physiology · 2019Review
- Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- microRNA-352 regulates collateral vessel growth induced by elevated fluid shear stress in the rat hind limb.Scientific reports · 2017Article
- Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Remodeling.Microcirculation (New York, N.Y. : 1994) · 2016Review
- Nitric Oxide Increases Arterial Endotheial Permeability through Mediating VE-Cadherin Expression during Arteriogenesis.PloS one · 2015Article
- Vitamin D: evidence for an association with coronary collateral circulation development?Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2015Article
- The collateral circulation of the heart.BMC medicine · 2013Review
- Significant correlation between endothelial nitric oxide synthase (eNOS) expression and alveolar repair in elastase-induced rat pulmonary emphysema.Surgery today · 2013Article
- Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins.Current drug targets · 2013Review
- Effect of shunting of collateral flow into the venous system on arteriogenesis and angiogenesis in rabbit hind limb.Acta histochemica et cytochemica · 2013Article
- Exercise training and peripheral arterial disease.Comprehensive Physiology · 2012Review
- Macrophages in collateral arteriogenesis.Frontiers in physiology · 2012Article
- Review
- Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis.Circulation research · 2010Article
- Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis.Journal of cellular and molecular medicine · 2009Article
- Trpv4 induces collateral vessel growth during regeneration of the arterial circulation.Journal of cellular and molecular medicine · 2009Article
- Milieu intérieur: the search for myocardial arteriogenic signals.Journal of the American College of Cardiology · 2009Article
- Role of endothelial nitric oxide synthetase in arteriogenesis after stroke in mice.Neuroscience · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) has been demonstrated to play an important role in angiogenesis, and also to be involved in collateral vessel growth. The expression of endothelial NO synthase (eNOS) is moderated partly by blood flow-induced mechanical factors, i.e., shear stress. The purpose of this study was to evaluate how the expression of eNOS correlates with the development of collateral vessels in dog heart, induced by chronic occlusion of the left circumflex artery. Immunoconfocal microscopy using an antibody against eNOS was used to detect expression of eNOS in different stages of arteriogenesis. Collateral vessels were classified into normal, growing and mature vessels by using the cytoskeleton marker desmin. Expression of the growth factors bFGF and metallproteinase-2 (MMP-2) was also examined. The data show that in normal arteriolar vessels, expression of eNOS is very low, but in growing collateral vessel there is a 6.2-fold increase, which, however, returned to normal levels in mature collateral vessels. The expression of eNOS was localized only in endothelium, either in normal or growing vessels. bFGF was very weakly stained in normal vessels, but highly expressed in growing collateral vessels. MMP-2 was strongly stained in neointima, but very weak in endothelium. In addition, we also examined expression of iNOS because iNOS may be induced in vessel injury or in disease states, but it was not detected in either normal or growing collateral vessels. Our findings indicate that the expression pattern of eNOS is closely associated with the development of collateral vessels, suggesting that eNOS plays an important role in arteriogenesis.
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