ArticleOncogene2004
Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- Eukaryotic viruses encode the ribosomal protein eL40.Npj viruses · 2024Article
- Multi-Omics Analysis Reveals the Potential Effects of Maternal Dietary Restriction on Fetal Muscle Growth and Development.Nutrients · 2023Article
- Pathogenesis and Therapeutic Targets of Focal Cortical Dysplasia Based on Bioinformatics Analysis.Neurochemical research · 2022Article
- Downregulated RPS-30 in Angiostrongylus cantonensis L5 plays a defensive role against damage due to oxidative stress.Parasites & vectors · 2020Article
- Knockdown of RPL34 suppresses osteosarcoma cell proliferation likely through EIF3/FAU signaling pathway.Translational cancer research · 2019Article
- Numerous cultivated and uncultivated viruses encode ribosomal proteins.Nature communications · 2019Article
- Are snoRNAs and snoRNA host genes new players in cancer?Nature reviews. Cancer · 2012Review
- Pluripotency-associated genes in human nasopharyngeal carcinoma CNE-2 cells are reactivated by a unique epigenetic sub-microenvironment.BMC cancer · 2010Article
- RACK-1 overexpression protects against goniothalamin-induced cell death.Toxicology letters · 2009Article
- GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer.Oncogene · 2009Article
- Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.Breast cancer research : BCR · 2009Article
- Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13.World journal of surgery · 2008Article
- The fur seal-a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution.Journal of mammary gland biology and neoplasia · 2007Review
- Isolation of genes controlling apoptosis through their effects on cell survival.Gene therapy & molecular biology · 2006Article
- Identification by functional cloning from a retroviral cDNA library of cDNAs for ribosomal protein L36 and the 10-kDa heat shock protein that confer cisplatin resistance.Molecular pharmacology · 2006Article
- Transcriptional modulation of TCR, Notch and Wnt signaling pathways in SEB-anergized CD4+ T cells.Genes and immunity · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional expression cloning is a powerful strategy for identifying critical steps in biological pathways independently of prior assumptions. It is particularly suitable for the identification of molecules crucial to the control of apoptosis. Our screen for sequences suppressing T-cell apoptosis isolated a sequence antisense to fau (Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV)-associated ubiquitously expressed gene). The fox gene in FBR murine osteosarcoma virus is also antisense to fau and several reports have indicated that fau displays tumour suppressor and oncogenic properties in different contexts. Our observations indicate that the fau antisense sequence suppresses expression of endogenous fau mRNA and produces resistance to apoptosis induced both by the glucocorticoid analogue dexamethasone' by ultraviolet radiation, and by the anticancer drug cisplatin. In all cases, colony-forming ability is protected, indicating that fau affects the critical events prior to commitment to cell death. Overexpression of fau in the sense orientation induces cell death, which is inhibited both by Bcl-2 and by inhibition of caspases, in line with its proposed role in apoptosis.
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Registered trials
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