ArticleMolecular and cellular biology2004
Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Structure and Function of SNM1 Family Nucleases.Advances in experimental medicine and biology · 2023Review
- The SNM1A DNA repair nuclease.DNA repair · 2020Review
- Bufalin alters gene expressions associated DNA damage, cell cycle, and apoptosis in human lung cancer NCI-H460 cells in vitro.Molecules (Basel, Switzerland) · 2014Article
- microRNA-34a promotes DNA damage and mitotic catastrophe.Cell cycle (Georgetown, Tex.) · 2013Article
- Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/C(Cdh1).Chinese journal of cancer · 2012Article
- Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27.Cell cycle (Georgetown, Tex.) · 2011Article
- MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway.Nature cell biology · 2011Article
- The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.Aging cell · 2010Article
- Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.Oncogene · 2010Article
- SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.The EMBO journal · 2010Article
- The multifunctional SNM1 gene family: not just nucleases.Future oncology (London, England) · 2010Review
- SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.Biochemical and biophysical research communications · 2008Article
- Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links.Oncogene · 2008Article
- Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation.DNA repair · 2008Article
- CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis.Translational oncology · 2008Article
- Mammalian SNM1 is required for genome stability.Molecular genetics and metabolism · 2008Article
- The hSNM1 protein is a DNA 5'-exonuclease.Nucleic acids research · 2007Article
- Tying the loose ends together in DNA double strand break repair with 53BP1.Cell division · 2006Article
- 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Jun activation domain-binding protein 1 is required for mitotic checkpoint activation via its involvement in hyperphosphorylation of 53BP1.Journal of cancer research and clinical oncology · 2005Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Spindle poisons represent an important class of anticancer drugs that act by interfering with microtubule polymerization and dynamics and thereby induce mitotic checkpoints and apoptosis. Here we show that mammalian SNM1 functions in an early mitotic stress checkpoint that is distinct from the well-characterized spindle checkpoint that regulates the metaphase-to-anaphase transition. Specifically, we found that compared to wild-type cells, Snm1-deficient mouse embryonic fibroblasts exposed to spindle poisons exhibited elevated levels of micronucleus formation, decreased mitotic delay, a failure to arrest in mitosis prior to chromosome condensation, supernumerary centrosomes, and decreased viability. In addition, we show that both Snm1 and 53BP1, previously shown to interact, coimmunoprecipitate with components of the anaphase-promoting complex (APC)/cyclosome. These findings suggest that Snm1 is a component of a mitotic stress checkpoint that negatively targets the APC prior to chromosome condensation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.