ArticleMolecular and cellular biology2004
SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 72 citations in OpenAlex.
- GWSF-EuSWAP70 gene expression to enhance gray mold resistance in Arabidopsis thaliana.BMC plant biology · 2025Article
- IL-33/ST2 axis mediates diesel exhaust particles-induced mast cell activation.Molecular medicine (Cambridge, Mass.) · 2024Article
- The F-actin bundler SWAP-70 promotes tumor metastasis.Life science alliance · 2024Article
- Role of Dynamic Actin Cytoskeleton Remodeling in Foxp3Frontiers in immunology · 2022Article
- Detection of selection signatures for response to Aleutian mink disease virus infection in American mink.Scientific reports · 2021Article
- The Art of Mast Cell Adhesion.Cells · 2020Review
- Dynamic alterations of genome and transcriptome in KRAS G13D mutant CRC PDX model treated with cetuximab.BMC cancer · 2020Article
- MicroRNA Regulation of the Small Rho GTPase Regulators-Complexities and Opportunities in Targeting Cancer Metastasis.Cancers · 2020Review
- A proteome-wide assessment of the oxidative stress paradigm for metal and metal-oxide nanomaterials in human macrophages.NanoImpact · 2020Article
- SWAP70 is a universal GEF-like adaptor for tethering actin to phagosomes.Small GTPases · 2019Article
- Kit-independent mast cell adhesion mediated by Notch.International immunology · 2019Article
- M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells.PloS one · 2017Article
- Identification of a Novel Alternatively Spliced Form of Inflammatory Regulator SWAP-70-Like Adapter of T Cells.International journal of inflammation · 2017Article
- The F-actin modulator SWAP-70 controls podosome patterning in osteoclasts.Bone reports · 2016Article
- SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis.Cell reports · 2016Article
- SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.Journal of cell science · 2015Article
- The guanine exchange factor SWAP70 mediates vGPCR-induced endothelial plasticity.Cell communication and signaling : CCS · 2015Article
- Combination therapy for KIT-mutant mast cells: targeting constitutive NFAT and KIT activity.Molecular cancer therapeutics · 2014Article
- Switch-associated protein 70 antibodies in multiple sclerosis: possible association with disease progression.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2014Article
- The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
SWAP-70, an unusual phosphatidylinositol-3-kinase-dependent protein that interacts with the RhoGTPase Rac, is highly expressed in mast cells. Cultured bone marrow mast cells (BMMC) from SWAP-70(-/-) mice are reduced in FcepsilonRI-triggered degranulation. This report describes the hitherto-unknown role of SWAP-70 in c-kit receptor signaling, a key proliferation and differentiation pathway in mast cells. Consistent with the role of Rac in cell motility and regulation of the actin cytoskeleton, mutant cells show abnormal actin rearrangements and are deficient in migration in vitro and in vivo. SWAP-70(-/-) BMMC are impaired in calcium flux, in proper translocation and activity of Akt kinase (required for mast cell activation and survival), and in translocation of Rac1 and Rac2 upon c-kit stimulation. Adhesion to fibronectin is reduced, but homotypic cell association induced through c-kit is strongly increased in SWAP-70(-/-) BMMC. Homotypic association requires extracellular Ca(2+) and depends on the integrin alpha(L)beta(2) (LFA-1). ERK is hyperactivated upon c-kit signaling in adherent and dispersed mutant cells. Together, we suggest that SWAP-70 is an important regulator of specific effector pathways in c-kit signaling, including mast cell activation, migration, and cell adhesion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.