ArticleJournal of virology2004
Bracoviruses contain a large multigene family coding for protein tyrosine phosphatases.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
- The role of a viral symbiont in the thermal mismatch of host-parasitoid interactions.The Journal of experimental biology · 2026Article
- Parasitic castration by a viral protein tyrosine phosphatase targeting the host cell cycle checkpoint protein Rad9A.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Characterizing virulence differences in a parasitoid wasp through comparative transcriptomic and proteomic.BMC genomics · 2024Article
- Baculovirus entry into the central nervous system ofOpen biology · 2024Article
- An Overview of Ovarian Calyx Fluid Proteins ofBiomolecules · 2023Article
- A PolydnavirusViruses · 2022Article
- Role of Ovarian Proteins Secreted byInsects · 2021Article
- Cotesia congregata Bracovirus Circles EncodingJournal of virology · 2018Article
- Novel Factors of Viral Origin Inhibit TOR Pathway Gene Expression.Frontiers in physiology · 2018Article
- Characterization of a protein tyrosine phosphatase as a host factor promoting baculovirus replication in silkworm, Bombyx mori.Developmental and comparative immunology · 2016Article
- Polydnaviruses: From discovery to current insights.Virology · 2015Review
- Functional annotation of Cotesia congregata bracovirus: identification of viral genes expressed in parasitized host immune tissues.Journal of virology · 2014Article
- Article
- When parasitic wasps hijacked viruses: genomic and functional evolution of polydnaviruses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Adaptive selection on bracovirus genomes drives the specialization of Cotesia parasitoid wasps.PloS one · 2013Article
- Evolutionary mechanisms driving the evolution of a large polydnavirus gene family coding for protein tyrosine phosphatases.BMC evolutionary biology · 2012Article
- Deep sequencing identifies viral and wasp genes with potential roles in replication of Microplitis demolitor Bracovirus.Journal of virology · 2012Article
- Polydnaviruses of Parasitic Wasps: Domestication of Viruses To Act as Gene Delivery Vectors.Insects · 2012Review
- Article
- The impact on microtubule network of a bracovirus IkappaB-like protein.Cellular and molecular life sciences : CMLS · 2010Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between parasitic wasps and bracoviruses constitutes one of the few known mutualisms between viruses and eukaryotes. The virions produced in the wasp ovaries are injected into host lepidopteran larvae, where virus genes are expressed, allowing successful development of the parasite by inducing host immune suppression and developmental arrest. Bracovirus-bearing wasps have a common phylogenetic origin, and contemporary bracoviruses are hypothesized to have been inherited by chromosomal transmission from a virus that originally integrated into the genome of the common ancestor wasp living 73.7 +/- 10 million years ago. However, so far no conserved genes have been described among different braconid wasp subfamilies. Here we show that a gene family is present in bracoviruses of different braconid wasp subfamilies (Cotesia congregata, Microgastrinae, and Toxoneuron nigriceps, Cardiochilinae) which likely corresponds to an ancient component of the bracovirus genome that might have been present in the ancestral virus. The genes encode proteins belonging to the protein tyrosine phosphatase family, known to play a key role in the control of signal transduction pathways. Bracovirus protein tyrosine phosphatase genes were shown to be expressed in different tissues of parasitized hosts, and two protein tyrosine phosphatases were produced with recombinant baculoviruses and tested for their biochemical activity. One protein tyrosine phosphatase is a functional phosphatase. These results strengthen the hypothesis that protein tyrosine phosphatases are involved in virally induced alterations of host physiology during parasitism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.