ArticleProceedings of the National Academy of Sciences of the United States of America2004
A dual-genome Symbiosis Chip for coordinate study of signal exchange and development in a prokaryote-host interaction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.
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Who cites it
129 citing papers in PubMed, 291 citations in OpenAlex.
- Review
- Mobile gene clusters and coexpressed plant-rhizobium pathways drive partner quality variation in symbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Protein import into bacterial endosymbionts and evolving organelles.The FEBS journal · 2025Review
- The Fsr transporter ofMicrobiology (Reading, England) · 2025Article
- Transcriptomic Response ofInternational journal of molecular sciences · 2024Article
- Microbiome properties in the root nodules ofMicrobiology spectrum · 2024Article
- Article
- A protease and a lipoprotein jointly modulate the conserved ExoR-ExoS-ChvI signaling pathway critical in Sinorhizobium meliloti for symbiosis with legume hosts.PLoS genetics · 2023Article
- A signal peptide peptidase is required for ER-symbiosome proximal association and protein secretion.Nature communications · 2023Article
- Review
- Sugarcane Genotypes with Contrasting Biological Nitrogen Fixation Efficiencies Differentially Modulate Nitrogen Metabolism, Auxin Signaling, and Microorganism Perception Pathways.Plants (Basel, Switzerland) · 2022Article
- DNA Methylation inmSystems · 2022Article
- Maintaining osmotic balance in legume nodules.Journal of experimental botany · 2022Article
- Article
- How Rhizobia Adapt to the Nodule Environment.Journal of bacteriology · 2021Article
- Early stages of legume-rhizobia symbiosis are controlled by ABCG-mediated transport of active cytokinins.Nature plants · 2021Article
- Competition, Nodule Occupancy, and Persistence of Inoculant Strains: Key Factors in theFrontiers in plant science · 2021Review
- Genome-scale metabolic reconstruction of the symbiosis between a leguminous plant and a nitrogen-fixing bacterium.Nature communications · 2020Article
- Riboregulation in Nitrogen-Fixing Endosymbiotic Bacteria.Microorganisms · 2020Review
- Destabilization of the Tumor-Inducing Plasmid from an Octopine-TypeG3 (Bethesda, Md.) · 2019Article
69 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The soil-dwelling alpha-proteobacterium Sinorhizobium meliloti engages in a symbiosis with legumes: S. meliloti elicits the formation of plant root nodules where it converts dinitrogen to ammonia for use by the plant in exchange for plant photosynthate. To study the coordinate differentiation of S. meliloti and its legume partner during nodule development, we designed a custom Affymetrix GeneChip with the complete S. meliloti genome and approximately 10,000 probe sets for the plant host, Medicago truncatula. Expression profiling of free-living S. meliloti grown with the plant signal molecule luteolin in defined minimal and rich media or of strains altered in the expression of key regulatory proteins (NodD1, NodD3, and RpoN) confirms previous data and identifies previously undescribed regulatory targets. Analyses of root nodules show that this Symbiosis Chip allows the study of gene expression in both partners simultaneously. Our studies detail nearly 5,000 transcriptome changes in symbiosis and document complex transcriptional profiles of S. meliloti in different environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.